Farnsworth Norman R, Krause Elizabeth C, Bolton Judy L, Pauli Guido F, van Breemen Richard B, Graham James G
University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA.
Am J Clin Nutr. 2008 Feb;87(2):504S-8S. doi: 10.1093/ajcn/87.2.504S.
The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research began in 1999 with an emphasis on botanical dietary supplements for women's health. We have concentrated on plants that may improve women's health, especially to reduce hot flashes in menopausal women, alleviate the symptoms of premenstrual syndrome, and reduce persistent urinary tract infections. The primary focus of this article is to describe the operation of our center, from acquiring and identifying botanicals to isolating and identifying active constituents, to elucidating their mechanisms of action, and to conducting phase I and phase II clinical studies. Black cohosh (Actaea racemosa; syn Cimicifuga racemosa) has been used as a model to illustrate the steps involved in taking this plant from the field to clinical trials. Bioassays are described that were necessary to elucidate the pertinent biological studies of plant extracts and their mechanisms of action. We conclude that this type of research can only be successful with the use of a multidisciplinary approach.
伊利诺伊大学芝加哥分校/美国国立卫生研究院植物性膳食补充剂研究中心始于1999年，重点关注用于女性健康的植物性膳食补充剂。我们专注于可能改善女性健康的植物，特别是减少更年期女性的潮热、缓解经前综合征症状以及减少持续性尿路感染。本文的主要重点是描述我们中心的运作，从获取和鉴定植物药到分离和鉴定活性成分，再到阐明其作用机制，以及进行I期和II期临床研究。黑升麻（Actaea racemosa；同义词Cimicifuga racemosa）已被用作一个模型，以说明将这种植物从田间带到临床试验所涉及的步骤。文中描述了阐明植物提取物相关生物学研究及其作用机制所必需的生物测定法。我们得出结论，这类研究只有采用多学科方法才能取得成功。
