Steegers E A, van Lakwijk H P, Fast J H, Godschalx A W, Jongsma H W, Eskes T K, Symonds E M, Hein P R
Department of Obstetrics and Gynaecology, Catholic University of Nijmegen, Sint Radbound Hospital, The Netherlands.
Br J Obstet Gynaecol. 1991 Feb;98(2):202-6. doi: 10.1111/j.1471-0528.1991.tb13369.x.
Plasma atrial natriuretic peptide (ANP), right and left atrial areas and the diameter of the left atrium were studied serially during normal pregnancy and at 6 weeks post partum in 21 nulliparous women. Concentrations of ANP in plasma were significantly elevated during mid-pregnancy. Thereafter ANP levels were not significantly different from those at 6 weeks after delivery. All atrial measurements were significantly increased in the third trimester of pregnancy, but none was significantly correlated with the plasma ANP concentrations. This might point at an altered mechanism of ANP secretion, which may be part of a physiological adaptive process to sustain the hypervolaemia of pregnancy.
对21名未生育女性在正常孕期及产后6周时，连续研究了血浆心钠素（ANP）、左右心房面积及左心房直径。孕期中期血浆ANP浓度显著升高。此后，ANP水平与产后6周时无显著差异。孕期晚期所有心房测量值均显著增加，但均与血浆ANP浓度无显著相关性。这可能表明ANP分泌机制发生了改变，这可能是维持孕期血容量过多的生理适应性过程的一部分。
