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液体运输:给困惑者的指南。

Fluid transport: a guide for the perplexed.

作者信息

Hill A E

机构信息

The Physiological Laboratory, Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, UK.

出版信息

J Membr Biol. 2008 May;223(1):1-11. doi: 10.1007/s00232-007-9085-1. Epub 2008 Feb 8.

DOI:10.1007/s00232-007-9085-1
PMID:18259799
Abstract

Readers of the physiological literature may be excused if they feel that fluid transport has become a complex and confusing field that is difficult to understand and to assess. The major theories of fluid-transporting epithelia are examined here with respect to their ability to explain quasi-isotonic fluid transport and its modulation by salt transport, osmotic permeability and basal tonicity. The basics of each theory are set out concisely, and their pros and cons are made explicit. Finally, a comparison is made in table form indicating their overall performance in relation to the problems of this difficult but important field.

摘要

如果生理文献的读者觉得液体运输已成为一个复杂且令人困惑、难以理解和评估的领域,那也是情有可原的。本文将研究液体运输上皮的主要理论,看它们在解释准等渗液体运输及其受盐运输、渗透通透性和基础张力调节方面的能力。每个理论的基础都进行了简要阐述,并明确了其优缺点。最后,以表格形式进行比较,说明它们在这个困难但重要的领域中针对各种问题的总体表现。

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1
Fluid transport: a guide for the perplexed.液体运输:给困惑者的指南。
J Membr Biol. 2008 May;223(1):1-11. doi: 10.1007/s00232-007-9085-1. Epub 2008 Feb 8.
2
Salt-water coupling in leaky epithelia.渗漏上皮中的盐水偶联
J Membr Biol. 1980 Oct 31;56(3):177-82. doi: 10.1007/BF01869474.
3
Osmotic water flow in leaky epithelia.渗漏上皮中的渗透水流。
J Membr Biol. 1979 Dec 31;51(3-4):195-216. doi: 10.1007/BF01869084.
4
Local osmosis and isotonic transport.局部渗透与等渗转运。
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5
A central role for cell osmolarity in isotonic fluid transport across epithelia.细胞渗透压在上皮细胞等渗液体转运中起核心作用。
Biol Cell. 1985;55(3):239-44. doi: 10.1111/j.1768-322x.1985.tb00432.x.
6
Solute-solvent coupling in epithelia: a critical examination of the standing-gradient osmotic flow theory.上皮细胞中的溶质-溶剂偶联:对稳态梯度渗透流理论的批判性审视。
Proc R Soc Lond B Biol Sci. 1975 Jun 20;190(1098):99-114. doi: 10.1098/rspb.1975.0081.
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Physiology of salivary secretion.唾液分泌的生理学
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Standing-gradient osmotic flow. A mechanism for coupling of water and solute transport in epithelia.直立梯度渗透流。上皮细胞中水和溶质运输偶联的一种机制。
J Gen Physiol. 1967 Sep;50(8):2061-83. doi: 10.1085/jgp.50.8.2061.
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Mechanisms of water transport by epithelial cells.上皮细胞的水运输机制。
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The lateral intercellular space as osmotic coupling compartment in isotonic transport.细胞间隙作为渗透偶联隔室在等渗转运中的作用。
Acta Physiol (Oxf). 2009 Jan;195(1):171-86. doi: 10.1111/j.1748-1716.2008.01930.x. Epub 2008 Oct 28.

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Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex.通过水通道蛋白5和紧密连接复合体的跨细胞和细胞旁水运输途径之间的相互作用。
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3621-6. doi: 10.1073/pnas.0608384104. Epub 2007 Feb 21.
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A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands.大鼠水通道蛋白5基因中一种自然发生的点突变,影响其蛋白质生成以及唾液腺的水分泌。
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Transcriptomic and Network Analysis Identifies Shared and Unique Pathways across Dementia Spectrum Disorders.转录组学和网络分析确定了痴呆症谱障碍的共享和独特途径。
Int J Mol Sci. 2020 Mar 17;21(6):2050. doi: 10.3390/ijms21062050.
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How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure.抗高血压药物如何发挥作用?来自动脉血压肾脏调节研究的见解。
Front Physiol. 2016 Jul 29;7:320. doi: 10.3389/fphys.2016.00320. eCollection 2016.
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Response to "What do aquaporin knockout studies tell us about fluid transport in epithelia?" Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297-305.对《水通道蛋白基因敲除研究告诉了我们关于上皮细胞液体转运的哪些信息?》的回应。麦克拉伦OJ、斯内德J、克兰平EJ(2013年)《膜生物学杂志》246卷:297 - 305页
J Membr Biol. 2013 Sep;246(9):665-7. doi: 10.1007/s00232-013-9585-0. Epub 2013 Aug 22.
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Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities.跨人体呼吸上皮的离子转运的生物物理模型允许定量测定离子通透性。
Biophys J. 2013 Feb 5;104(3):716-26. doi: 10.1016/j.bpj.2012.12.040.
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What do aquaporin knockout studies tell us about fluid transport in epithelia?水通道蛋白敲除研究告诉了我们什么关于上皮细胞中的液体转运?
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9
Efficiency of primary saliva secretion: an analysis of parameter dependence in dynamic single-cell and acinus models, with application to aquaporin knockout studies.基础唾液分泌效率:动态单细胞和腺泡模型中参数依赖性分析,及其在水通道蛋白敲除研究中的应用。
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Osmoregulation and epithelial water transport: lessons from the intestine of marine teleost fish.渗透调节和上皮细胞水转运:来自海洋硬骨鱼类肠道的启示。
J Comp Physiol B. 2012 Jan;182(1):1-39. doi: 10.1007/s00360-011-0601-3. Epub 2011 Jul 7.
A new approach to epithelial isotonic fluid transport: an osmosensor feedback model.
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A model system for biological water transport.一种生物水运输的模型系统。
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