Oharaseki Toshiaki, Takahashi Kei, Yokouchi Yuki, Naoe Shiro
Department of Pathology, Toho University Ohashi Medical Center.
Nihon Rinsho. 2008 Feb;66(2):246-50.
Clinical and epidemiologic features suggest infectious agent or agents as a possible cause of Kawasaki disease; however, the etiology of Kawasaki disease still remains unknown. A number of microorganisms including bacteria, viruses, rickettsiae etc. were hypothesized as an etiology of the illness. Unfortunately, no specific agent that provides reproducible evidence has yet reported. The differences of histology between vasculitic disorders indicate the differences of etiology and pathogenesis. The histological characteristics that abnormal activation of monocytes/macrophages is caused in the vascular lesions of Kawasaki disease can be of help when considering the etiology of Kawasaki disease.
临床和流行病学特征表明，一种或多种感染因子可能是川崎病的病因；然而，川崎病的病因仍然不明。许多微生物，包括细菌、病毒、立克次氏体等，都被假定为该病的病因。不幸的是，尚无关于能提供可重复证据的特定病原体的报道。血管炎疾病之间的组织学差异表明病因和发病机制的不同。在考虑川崎病的病因时，川崎病血管病变中单核细胞/巨噬细胞异常激活这一组织学特征可能会有所帮助。
