da Costa Aurélio Ribeiro, Pinto-Neto Aarão Mendes, Amorim Melania, Paiva Lúcia Helena Simões Costa, Scavuzzi Adriana, Schettini Juliana
Department of Obstetrics and Gynecology, Institute for Maternal/Infant Health, Perbambuco, Brazil.
J Minim Invasive Gynecol. 2008 Jan-Feb;15(1):67-73. doi: 10.1016/j.jmig.2007.08.596.
To compare results of diagnostic hysteroscopy in postmenopausal women using misoprostol for cervical ripening.
A randomized, placebo-controlled clinical trial (Canadian Task Force classification Ib).
Hospital Barão de Lucena, Instituto Materno Infantil de Pernambuco.
One hundred-twenty postmenopausal women.
Postmenopausal women received 200 microg of vaginal misoprostol or placebo before hysteroscopy.
Variables measured were procedure time, frequency of hysteroscopy carried out in each group (misoprostol and placebo), degree of pain during procedure, need for dilation, side effects, and complications of hysteroscopy. The chi2, Fisher's exact, and Mann-Whitney tests were used and considered significant when alpha error was <5%. There were similarities between the groups in age (p = .09), body mass index (p = .55), time since menopause (p = .52), and genital bleeding (p = .52). Pain during the procedure, as measured by visual analog scale, was less severe in the misoprostol group than in the placebo group (median of 05 vs 07, p = .02), but there were similarities in duration (2.4 min vs 2.0 min, p = .3), pain during procedure and biopsy (p = .74 vs p = .19), need for dilation (p = .66), side effects, and complications. There were no differences in severity of post-procedure pain.
Previous use of misoprostol reduced pain severity during hysteroscopy.
比较米索前列醇用于绝经后妇女宫颈成熟后诊断性宫腔镜检查的结果。
一项随机、安慰剂对照临床试验（加拿大工作组分类Ib）。
伯南布哥州母婴研究所巴朗德卢塞纳医院。
120名绝经后妇女。
绝经后妇女在宫腔镜检查前接受200微克阴道米索前列醇或安慰剂。
测量的变量包括手术时间、每组（米索前列醇组和安慰剂组）进行宫腔镜检查的频率、手术过程中的疼痛程度、扩张需求、副作用及宫腔镜检查的并发症。使用卡方检验、费舍尔精确检验和曼-惠特尼检验，当α错误<5%时认为具有统计学意义。两组在年龄（p = 0.09）、体重指数（p = 0.55）、绝经时间（p = 0.52）和生殖器出血情况（p = 0.52）方面相似。通过视觉模拟量表测量，米索前列醇组手术过程中的疼痛程度低于安慰剂组（中位数分别为05 vs 07，p = 0.02），但在持续时间（2.4分钟 vs 2.0分钟，p = 0.3）、手术和活检时的疼痛（p = 0.74 vs p = （此处原文有误，推测为0.19））、扩张需求（p = 0.66）、副作用及并发症方面相似。术后疼痛严重程度无差异。
先前使用米索前列醇可降低宫腔镜检查期间的疼痛严重程度。
