Lin Herng-Ching, Xirasagar Sudha, Chen Chi-Hung, Hwang Yi-Ting
School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
Am J Respir Crit Care Med. 2008 May 1;177(9):989-94. doi: 10.1164/rccm.200706-813OC. Epub 2008 Feb 8.
Although several studies have investigated volume-outcome relationships for surgical procedures, there has been no such study of intensive care unit (ICU) patients admitted for pneumonia.
This study examines associations between in-hospital mortality of ICU-admitted pneumonia patients and their attending physician's case volume.
We used 2002-2004 claims data from Taiwan's National Health Insurance for all 87,479 adult ICU admissions for pneumonia. Patients were assigned to one of four groups, on the basis of their physician's ICU pneumonia case volume (low volume, <36 cases; medium volume, 37-114 cases; high volume, 118-314 cases; and very high volume, > or =315 cases). Generalized estimating equations (conditional on hospital, and unconditional) were used, adjusting for physician demographics and specialty, hospital characteristics, patient characteristics (including clinical severity and comorbidities), and physician-level random effect (clustering effect) to assess whether physicians' case volume predicts in-hospital mortality.
In-hospital mortality systematically declined with increasing physician case volume: 14.7, 14.3, 11.4, and 8.1% from low-volume to very-high-volume groups. Adjusted unconditional odds of mortality among low-volume physicians' patients were 2.04 times those of very-high-volume physicians, 1.35 times that of high-volume physicians, and 1.09 times those of medium-volume physicians (all P < 0.001). The relationship is sustained when the odds are estimated conditional on hospital, when initial 5-day mortality is separated from 30-day mortality, and when pulmonologists' and critical care specialists' patients are studied separately.
Physician volume significantly predicts inpatient mortality among ICU patients with pneumonia. Detailed study of clinical approaches, decision algorithms, and treatment plans of high-volume physicians is recommended to identify possible mediating factors in this phenomenon.
尽管已有多项研究探讨了外科手术的手术量与治疗结果之间的关系,但尚未有针对因肺炎入住重症监护病房(ICU)的患者进行此类研究。
本研究旨在探讨入住ICU的肺炎患者的院内死亡率与其主治医生的病例量之间的关联。
我们使用了台湾全民健康保险2002 - 2004年的理赔数据,涵盖了所有87479例因肺炎入住成人ICU的病例。根据医生的ICU肺炎病例量,将患者分为四组(低病例量组,<36例;中等病例量组,37 - 114例;高病例量组,118 - 314例;极高病例量组,≥315例)。使用广义估计方程(以医院为条件的和无条件的),对医生的人口统计学和专业、医院特征、患者特征(包括临床严重程度和合并症)以及医生层面的随机效应(聚类效应)进行调整,以评估医生的病例量是否可预测院内死亡率。
随着医生病例量的增加,院内死亡率呈系统性下降:从低病例量组到极高病例量组分别为14.7%、14.3%、11.4%和8.1%。低病例量医生的患者经调整后的无条件死亡几率是极高病例量医生的2.04倍,是高病例量医生的1.35倍,是中等病例量医生的1.09倍(所有P < 0.001)。当以医院为条件估计几率时、将初始5天死亡率与30天死亡率分开时以及分别研究肺科医生和重症监护专科医生的患者时,这种关系仍然存在。
医生的病例量显著预测了ICU肺炎患者的住院死亡率。建议对高病例量医生的临床方法、决策算法和治疗计划进行详细研究,以确定这一现象中可能的中介因素。