Kao Winston W-Y, Xia Ying, Liu Chia-Yang, Saika Shizuya
Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45267-0838, USA.
Ocul Surf. 2008 Jan;6(1):9-23.
Interactions and signaling between mesenchymal and epithelial cells are essential for morphogenesis, organogenesis, cell differentiation, and growth of cornea and eyelids during embryogenesis. These bidirectional interactions are mediated by complex regulatory networks that coordinate the proliferation, differentiation, and cell fate determination involved in tissue morphogenesis. All the signaling pathways involved are indispensable, but it is not clear whether each acts alone or whether they integrate to control events in various aspects of ocular surface development. This review discusses known signaling transduction pathways involved in the morphogenesis of the cornea and eyelids during embryonic development and homeostasis in adults, using genetically modified experimental animal models.
间充质细胞与上皮细胞之间的相互作用和信号传导对于胚胎发育过程中角膜和眼睑的形态发生、器官发生、细胞分化及生长至关重要。这些双向相互作用由复杂的调控网络介导，该网络协调组织形态发生过程中涉及的增殖、分化及细胞命运决定。所有涉及的信号通路都是不可或缺的，但尚不清楚它们是单独起作用还是相互整合以控制眼表发育各个方面的事件。本综述利用基因修饰实验动物模型，讨论了胚胎发育过程中角膜和眼睑形态发生以及成体稳态中已知的信号转导通路。
