Chui Jeanie, Di Girolamo Nick, Wakefield Denis, Coroneo Minas T
Inflammatory Diseases Research Unit, Department of Pathology, University of New South Wales, and Department of Ophthalmology, University of New South Wales at Prince of Wales Hospital, Sydney, Australia.
Ocul Surf. 2008 Jan;6(1):24-43. doi: 10.1016/s1542-0124(12)70103-9.
Pterygium is a disease of the ocular surface that is associated with chronic UV exposure and is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix breakdown. Although pterygium is not fully understood, significant progress has been made toward understanding the mechanisms involved in its pathogenesis. In this review, we provide an update on the signaling pathways activated by UV light that result in induction of mediators responsible for the growth of pterygium. We also review the recent genetic studies on hereditary factors and provide a brief overview of the role of epithelial mesenchymal transition, bone marrow progenitor cells, and neuronal signals that may also contribute to the pathogenesis of pterygium. Therapeutic options for pterygium are discussed based on the mechanisms that perpetuate its growth.
翼状胬肉是一种眼表疾病，与长期紫外线暴露相关，其特征为增生、炎症浸润、纤维化、血管生成和细胞外基质破坏。尽管翼状胬肉的发病机制尚未完全明确，但在了解其发病过程中涉及的机制方面已取得了重大进展。在本综述中，我们更新了关于紫外线激活的信号通路的研究进展，这些信号通路可诱导导致翼状胬肉生长的介质。我们还回顾了近期关于遗传因素的研究，并简要概述了上皮-间质转化、骨髓祖细胞和神经信号在翼状胬肉发病机制中可能发挥的作用。基于维持翼状胬肉生长的机制讨论了其治疗选择。
