宿主遗传学在 HIV 相关神经认知障碍易感性中的作用。
The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders.
机构信息
National Neurological AIDS Bank, Department of Neurology, University of California Los Angeles - David Geffen School of Medicine, 11645 Wilshire Blvd., Suite 770, Los Angeles, CA, 90025, USA.
出版信息
AIDS Behav. 2009 Feb;13(1):118-32. doi: 10.1007/s10461-008-9360-x. Epub 2008 Feb 9.
Abstract
Despite progress in the treatment of the Human Immunodeficiency virus (HIV), there continues to be a high prevalence of infected individuals who develop neurocognitive deficits and disorders. Our understanding of the potential cause of HIV-associated neurocognitive disorders (HAND) continues to develop on many fronts. Among them is the study of host genetics. Here, we review the most current information regarding the association between host genetics and risk for HIV infection, AIDS, and HAND. We focus on the role of dopamine dysfunction in the etiology of HAND, and propose a number of genetic polymorphisms within genes related to dopaminergic functioning and other neurobiological factors that may confer vulnerability or protection against HAND.
摘要
尽管在人类免疫缺陷病毒 (HIV) 的治疗方面取得了进展，但仍有大量感染个体出现神经认知缺陷和障碍。我们对 HIV 相关神经认知障碍 (HAND) 的潜在病因的理解在许多方面仍在不断发展。其中包括宿主遗传学的研究。在这里，我们回顾了关于宿主遗传学与 HIV 感染、艾滋病和 HAND 风险之间关联的最新信息。我们重点介绍了多巴胺功能障碍在 HAND 病因学中的作用，并提出了与多巴胺能功能和其他神经生物学因素相关的基因中的一些遗传多态性，这些因素可能使人易患 HAND 或对 HAND 具有保护作用。
相似文献
1
The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders.宿主遗传学在 HIV 相关神经认知障碍易感性中的作用。
AIDS Behav. 2009 Feb;13(1):118-32. doi: 10.1007/s10461-008-9360-x. Epub 2008 Feb 9.
2
Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults.多巴胺相关基因的功能多态性：对 HIV+ 成年人神经认知功能的影响。
J Clin Exp Neuropsychol. 2012;34(1):78-91. doi: 10.1080/13803395.2011.623118. Epub 2011 Nov 14.
3
Risk Factors and Pathogenesis of HIV-Associated Neurocognitive Disorder: The Role of Host Genetics.HIV 相关神经认知障碍的风险因素和发病机制：宿主遗传学的作用。
Int J Mol Sci. 2018 Nov 14;19(11):3594. doi: 10.3390/ijms19113594.
4
The longitudinal and interactive effects of HIV status, stimulant use, and host genotype upon neurocognitive functioning.人类免疫缺陷病毒（HIV）感染状态、兴奋剂使用及宿主基因型对神经认知功能的纵向及交互作用。
J Neurovirol. 2014 Jun;20(3):243-57. doi: 10.1007/s13365-014-0241-y. Epub 2014 Apr 16.
5
The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection.与多巴胺相关的基因多态性，如脑源性神经营养因子（BDNF）、儿茶酚-O-甲基转移酶（COMT）、多巴胺D2受体（DRD2）、多巴胺D3受体（DRD3）和多巴胺D4受体（DRD4），与脑脊液中多巴胺水平的变化以及HIV感染频率无关。
J Neural Transm (Vienna). 2017 Apr;124(4):501-509. doi: 10.1007/s00702-016-1659-6. Epub 2016 Dec 1.
6
HIV-associated neurocognitive disorders (HAND).人类免疫缺陷病毒相关神经认知障碍（HAND）
Isr Med Assoc J. 2015 Jan;17(1):54-9.
7
[Posttraumatic stress disorder (PTSD) as a consequence of the interaction between an individual genetic susceptibility, a traumatogenic event and a social context].[创伤后应激障碍（PTSD）作为个体遗传易感性、创伤性事件和社会环境之间相互作用的结果]
Encephale. 2012 Oct;38(5):373-80. doi: 10.1016/j.encep.2011.12.003. Epub 2012 Jan 24.
8
The molecular genetics of cognition: dopamine, COMT and BDNF.认知的分子遗传学：多巴胺、儿茶酚-O-甲基转移酶与脑源性神经营养因子
Genes Brain Behav. 2006 Jun;5(4):311-28. doi: 10.1111/j.1601-183X.2005.00163.x.
9
Neuropsychological Assessment of 412 HIV-Infected Individuals in São Paulo, Brazil.巴西圣保罗 412 例 HIV 感染者的神经心理学评估。
AIDS Patient Care STDS. 2018 Jan;32(1):1-8. doi: 10.1089/apc.2017.0202.
10
Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV.HIV相关神经认知障碍神经发病机制的多水平分析
J Neurovirol. 2016 Aug;22(4):431-41. doi: 10.1007/s13365-015-0410-7. Epub 2015 Dec 4.
引用本文的文献
1
7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder.7,8-二羟基黄酮可改善 HIV 相关神经认知障碍模型 Tg26 小鼠大脑的神经病理变化。
Sci Rep. 2021 Sep 16;11(1):18519. doi: 10.1038/s41598-021-97220-8.
2
A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates.胶质细胞 CCR5 在 HIV-1 Tat 和阿片类药物的神经病理学相互作用中的核心作用。
J Neuroinflammation. 2018 Oct 10;15(1):285. doi: 10.1186/s12974-018-1320-4.
3
Transcriptome analyses identify key cellular factors associated with HIV-1-associated neuropathogenesis in infected men.转录组分析确定了与受感染男性中HIV-1相关神经病变发生相关的关键细胞因子。
AIDS. 2017 Mar 13;31(5):623-633. doi: 10.1097/QAD.0000000000001379.
4
Serotonin-Related Gene Polymorphisms and Asymptomatic Neurocognitive Impairment in HIV-Infected Alcohol Abusers.血清素相关基因多态性与HIV感染的酗酒者无症状神经认知障碍
Genet Res Int. 2016;2016:7169172. doi: 10.1155/2016/7169172. Epub 2016 Mar 16.
5
Host genetic factors predisposing to HIV-associated neurocognitive disorder.易患与艾滋病相关的神经认知障碍的宿主遗传因素。
Curr HIV/AIDS Rep. 2014 Sep;11(3):336-52. doi: 10.1007/s11904-014-0222-z.
6
Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder.HIV 相关神经认知障碍的遗传、转录组和表观遗传学研究。
J Acquir Immune Defic Syndr. 2014 Apr 1;65(4):481-503. doi: 10.1097/QAI.0000000000000069.
7
Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.HIV 感染成人神经认知障碍和痴呆的全基因组关联研究。
Am J Med Genet B Neuropsychiatr Genet. 2012 Sep;159B(6):669-83. doi: 10.1002/ajmg.b.32071. Epub 2012 May 24.
8
Ketone bodies protection against HIV-1 Tat-induced neurotoxicity.酮体对 HIV-1 Tat 诱导的神经毒性的保护作用。
J Neurochem. 2012 Jul;122(2):382-91. doi: 10.1111/j.1471-4159.2012.07764.x. Epub 2012 May 17.
9
HIV associated dementia and HIV encephalitis II: Genes on chromosome 22 expressed in individually microdissected Globus pallidus neurons (Preliminary analysis).HIV相关性痴呆与HIV脑炎II：在单独显微切割的苍白球神经元中表达的22号染色体上的基因（初步分析）
Bioinformation. 2011;6(5):183-6. doi: 10.6026/97320630006183. Epub 2011 May 26.
10
HIV-1 envelope accessible surface and polarity: clade, blood, and brain.HIV-1包膜可及表面与极性：分支、血液及大脑
Bioinformation. 2011 Mar 22;6(2):48-56. doi: 10.6026/97320630006048.
本文引用的文献
1
The contribution of gene-environment interaction to psychopathology.基因-环境相互作用对精神病理学的影响。
Dev Psychopathol. 2007 Fall;19(4):989-1004. doi: 10.1017/S0954579407000491.
2
Updated research nosology for HIV-associated neurocognitive disorders.人类免疫缺陷病毒相关神经认知障碍的更新研究分类学
Neurology. 2007 Oct 30;69(18):1789-99. doi: 10.1212/01.WNL.0000287431.88658.8b. Epub 2007 Oct 3.
3
A whole-genome association study of major determinants for host control of HIV-1.一项关于宿主对HIV-1控制的主要决定因素的全基因组关联研究。
Science. 2007 Aug 17;317(5840):944-7. doi: 10.1126/science.1143767. Epub 2007 Jul 19.
4
Human genetics: variants in common diseases.人类遗传学：常见疾病中的变异
Nature. 2007 Feb 22;445(7130):828-30. doi: 10.1038/nature05568.
5
Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.表明DARPP - 32与人类额纹状体结构、功能及认知有关的遗传学证据。
J Clin Invest. 2007 Mar;117(3):672-82. doi: 10.1172/JCI30413. Epub 2007 Feb 8.
6
Dementia and neurocognitive disorders due to HIV-1 infection.由人类免疫缺陷病毒1型（HIV-1）感染引起的痴呆和神经认知障碍。
Semin Neurol. 2007 Feb;27(1):86-92. doi: 10.1055/s-2006-956759.
7
What is immune privilege (not)?什么是免疫赦免（并非什么是免疫赦免）？
Trends Immunol. 2007 Jan;28(1):12-8. doi: 10.1016/j.it.2006.11.004. Epub 2006 Nov 28.
8
DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability.DRD2基因C957T多态性与COMT基因Val158Met多态性在人类工作记忆能力方面存在相互作用。
Schizophr Res. 2007 Feb;90(1-3):104-7. doi: 10.1016/j.schres.2006.10.001. Epub 2006 Nov 17.
9
Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort.白细胞介素-1家族基因的全面基因分型及其与法国队列中艾滋病进展的关联。
J Infect Dis. 2006 Dec 1;194(11):1492-504. doi: 10.1086/508545. Epub 2006 Oct 26.
10
Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment.一组有神经功能障碍风险的西班牙裔女性中人类免疫缺陷病毒相关认知障碍的患病率。
J Neurovirol. 2006 Oct;12(5):356-64. doi: 10.1080/13550280600964576.
Zotero 插件