Blackburn George L, Wang Katherine A
Beth Israel Deaconess Medical Center, Center for the Study of Nutrition Medicine, Boston, MA 02215, USA.
Am J Clin Nutr. 2007 Sep;86(3):s878-81. doi: 10.1093/ajcn/86.3.878S.
Given that existing epidemiologic data on the correlation between dietary fat and breast cancer have been mixed, the Women's Intervention Nutrition Study was launched in 1987. This randomized clinical trial of 2437 women between the ages of 48 and 79 y with early-stage breast cancer tested the hypothesis that dietary fat reduction would increase the relapse-free survival rate. The study determined that low-fat dietary interventions can influence body weight and decrease breast cancer recurrence. Results showing a differential effect of diet on hormone-receptor-positive and -negative disease suggest that metabolic mechanisms involving insulin and insulin-like growth factor-1 may be involved in tumorigenesis. The results of the Women's Intervention Nutrition Study may therefore contribute to knowledge of the role of insulin resistance in cancer risk.
鉴于现有的关于膳食脂肪与乳腺癌之间相关性的流行病学数据参差不齐，“女性干预营养研究”于1987年启动。这项针对2437名年龄在48至79岁之间的早期乳腺癌女性的随机临床试验，检验了减少膳食脂肪会提高无复发生存率这一假设。该研究确定，低脂饮食干预可影响体重并降低乳腺癌复发率。结果显示饮食对激素受体阳性和阴性疾病有不同影响，这表明涉及胰岛素和胰岛素样生长因子-1的代谢机制可能参与肿瘤发生。因此，“女性干预营养研究”的结果可能有助于了解胰岛素抵抗在癌症风险中的作用。
