Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.
Nutrients. 2024 Aug 10;16(16):2644. doi: 10.3390/nu16162644.
Breast cancer (BC) is one of the most common cancers worldwide and a leading cause of cancer-related deaths among women. The escalating incidence of BC underscores the necessity of multi-level treatment. BC is a complex and heterogeneous disease involving many genetic, lifestyle, and environmental factors. Growing evidence suggests that nutrition intervention is an evolving effective prevention and treatment strategy for BC. In addition, the human microbiota, particularly the gut microbiota, is now widely recognized as a significant player contributing to health or disease status. It is also associated with the risk and development of BC. This review will focus on nutrition intervention in BC, including dietary patterns, bioactive compounds, and nutrients that affect BC prevention and therapeutic responses in both animal and human studies. Additionally, this paper examines the impacts of these nutrition interventions on modulating the composition and functionality of the gut microbiome, highlighting the microbiome-mediated mechanisms in BC. The combination treatment of nutrition factors and microbes is also discussed. Insights from this review paper emphasize the necessity of comprehensive BC management that focuses on the nutrition-microbiome axis.
乳腺癌（BC）是全球最常见的癌症之一，也是女性癌症相关死亡的主要原因。BC 发病率的不断上升突显出需要进行多层次的治疗。BC 是一种复杂的异质性疾病，涉及许多遗传、生活方式和环境因素。越来越多的证据表明，营养干预是一种不断发展的有效预防和治疗 BC 的策略。此外，人类微生物群，特别是肠道微生物群，现在被广泛认为是对健康或疾病状态有重要影响的因素。它也与 BC 的风险和发展有关。本综述将重点关注 BC 中的营养干预，包括饮食模式、生物活性化合物和营养素，这些都能在动物和人类研究中影响 BC 的预防和治疗反应。此外，本文还研究了这些营养干预措施对调节肠道微生物组组成和功能的影响，强调了微生物组介导的 BC 机制。还讨论了营养因素和微生物的联合治疗。本文的观点强调了综合 BC 管理的必要性，重点是关注营养-微生物组轴。
