Bidzseranova A, Telegdy G, Penke B
Institute of Pathophysiology, Szent-Györgyi A. University Medical School, Szeged, Hungary.
Brain Res Bull. 1991 Jan;26(1):177-80. doi: 10.1016/0361-9230(91)90206-y.
The effects of rat atrial natriuretic peptide (ANP 1-28) on passive avoidance behaviour were tested following its administration into the lateral brain ventricle in rats. Different doses of ANP 1-28 were administered immediately after the learning trial of passive avoidance behaviour and the effects on the consolidation of learning were tested 24 h later. ANP 1-28, in doses in the range 50-2000 ng/rat, caused a dose-dependent increase in passive avoidance latency. Selected doses (100, 200 and 500 ng/animal) were given 30 min before the learning trial. These doses lengthened the passive avoidance latency in a dose-dependent manner. When the peptide was given 30 min before the retention trial, there was no significant alteration in passive avoidance response. The data suggest that ANP 1-28 is able to facilitate the learning and consolidation of fear-motivated passive avoidance behaviour.
在大鼠侧脑室注射大鼠心房利钠肽（ANP 1-28）后，测试其对被动回避行为的影响。在被动回避行为学习试验后立即给予不同剂量的ANP 1-28，并在24小时后测试其对学习巩固的影响。剂量范围为50-2000 ng/大鼠的ANP 1-28可引起被动回避潜伏期呈剂量依赖性增加。在学习试验前30分钟给予选定剂量（100、200和500 ng/动物）。这些剂量以剂量依赖性方式延长了被动回避潜伏期。当在保留试验前30分钟给予该肽时，被动回避反应没有显著改变。数据表明，ANP 1-28能够促进恐惧驱动的被动回避行为的学习和巩固。
