Kovács A, Telegdy G
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Neuropeptides. 1992 Sep;23(1):51-4. doi: 10.1016/0143-4179(92)90010-t.
The effects of different doses of calcitonin gene-related peptide (CGRP) on passive avoidance behaviour were studied in male rats following its intracerebroventricular (i.c.v.) administration. Treatment with doses of 200 ng, 300 ng, 500 ng or 1 microgram was performed prior to learning, immediately and 6 h after the learning session and 30 min before the 24 h retention test. CGRP enhanced the avoidance latency in a dose-dependent manner at each time studied, with the exception of 6 h after the learning session. It is concluded that CGRP might be able to lengthen the passive avoidance latency by facilitating learning and memory formation.
在雄性大鼠脑室内注射不同剂量的降钙素基因相关肽（CGRP）后，研究其对被动回避行为的影响。在学习前、学习后即刻、学习后6小时以及24小时记忆测试前30分钟，分别给予200纳克、300纳克、500纳克或1微克的剂量进行处理。除学习后6小时外，在所研究的每个时间点，CGRP均以剂量依赖的方式延长了回避潜伏期。结论是，CGRP可能通过促进学习和记忆形成来延长被动回避潜伏期。
