Andersen Mads Varis Nis, Rosenberg Thomas, la Cour Morten, Kiilgaard Jens F, Prause Jan U, Alsbirk Poul Helge, Borch-Johnsen Knut, Peto Tunde, Carstensen Bendix, Bird Alan C
Department of Ophthalmology, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Ophthalmology. 2008 Apr;115(4):700-707.e1. doi: 10.1016/j.ophtha.2007.12.013. Epub 2008 Feb 11.
To examine the age- and gender-specific prevalence and describe the common phenotype of early age-related maculopathy (ARM) and late-stage age-related macular degeneration (AMD) among the Inuit in Greenland.
Population-based cross-sectional study.
All > or =60-year-olds born in Greenland and living in the communities of Nuuk and Sisimiut, Greenland.
The presence and form of early (ARM) and late age-related macular disease (AMD) were determined by grading color fundus photographs using the international classification and grading system for ARM and AMD.
Prevalences of ARM and AMD were assessed by masked grading of fundus photographs.
Overall, 695 persons were included in the study (response rate, 74.8%). Prevalence of any ARM was 52.3%. Age-related maculopathy was present in the worse eye in 50.0%, 58.8%, and 44.7% of age groups 60 to 69, 70 to 79, and > or =80, respectively. Prevalence of any AMD was 9.5%. Any AMD was present in the worse eye in 3.9%, 14.6%, and 43.2% of age groups 60 to 69, 70 to 79, and > or =80. Prevalences of pure geographic atrophy (GA) in one or both eyes, exudative degeneration in one or both eyes, and GA in one eye and exudative degeneration in the other eye were 2.3%, 6.1%, and 1.1%, respectively.
The prevalence of ARM is higher than in most other populations studied, and the prevalence of AMD in the oldest age group is higher than in most other populations studied. The prevalence of exudative degeneration is higher than the prevalence of GA, in contrast to findings in some of the Nordic countries-particularly Iceland-and earlier observations in Greenland.
研究格陵兰因纽特人中与年龄和性别相关的早期年龄相关性黄斑病变（ARM）及晚期年龄相关性黄斑变性（AMD）的患病率，并描述其常见表型。
基于人群的横断面研究。
所有出生于格陵兰且年龄≥60岁、居住在格陵兰努克和西西缪特社区的人。
采用国际ARM和AMD分类及分级系统，通过对彩色眼底照片进行分级来确定早期（ARM）和晚期年龄相关性黄斑疾病（AMD）的存在情况及类型。
通过对眼底照片进行盲法分级评估ARM和AMD的患病率。
总体而言，695人纳入本研究（应答率为74.8%）。任何ARM的患病率为52.3%。在60至69岁、70至79岁和≥80岁年龄组中，分别有50.0%、58.8%和44.7%的人在较差眼中存在年龄相关性黄斑病变。任何AMD的患病率为9.5%。在60至69岁、70至79岁和≥80岁年龄组中，分别有3.9%、14.6%和43.2%的人在较差眼中存在任何AMD。一只或两只眼睛单纯性地图样萎缩（GA）、一只或两只眼睛渗出性变性以及一只眼睛GA且另一只眼睛渗出性变性的患病率分别为2.3%、6.1%和1.1%。
ARM的患病率高于大多数其他研究人群，最年长年龄组中AMD的患病率也高于大多数其他研究人群。与一些北欧国家（特别是冰岛）的研究结果以及格陵兰早期观察结果相反，渗出性变性的患病率高于GA的患病率。
