土曲霉中两性霉素B耐药性的潜在基础。
Potential basis for amphotericin B resistance in Aspergillus terreus.
作者信息
Blum Gerhard, Perkhofer Susanne, Haas Hubertus, Schrettl Markus, Würzner Reinhard, Dierich Manfred P, Lass-Flörl Cornelia
机构信息
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria.
出版信息
Antimicrob Agents Chemother. 2008 Apr;52(4):1553-5. doi: 10.1128/AAC.01280-07. Epub 2008 Feb 11.
Abstract
This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus. The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance. The level of catalase production in A. terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action.
摘要
本研究调查了土曲霉对两性霉素B（AMB）内在耐药性的基础。麦角固醇含量、细胞壁组成和脂质过氧化水平对AMB耐药性均无影响。土曲霉中过氧化氢酶的产生水平显著高于烟曲霉（P<0.05）。由于氧化损伤与AMB的作用有关，这种较高水平的产生可能导致土曲霉对AMB产生耐药性。
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