Rastogi R B, Singhal R L
Can J Physiol Pharmacol. 1977 Jun;55(3):490-5. doi: 10.1139/y77-070.
Neonatal hyperthyroidism in rats induced by daily administration of L-triiodothyronine for 30 days since birth resulted in a significant rise in mobility and the metabolism of brain norepinephrine and dopamine. Whereas administration of lithium carbonate (60 mg/kg ip) to normal rats for 6 days produced no effect on spontaneous locomotor activity and increased the synthesis and possibly release of this monoamine in several brain regions, this antimanic drug antagonized the L-triiodothyronine-stimulated increases in mobility as well as norepinephrine and dopamine metabolism of hypothalamus, midbrain, striatum, and cerebral cortex. Furthermore, lithium treatment restored the activity of catechol-O-methyl transferase (EC 2.1.1.6) in young hyperthyroid rats to virtually normal limits. Our data suggest that antiphasic or damping effects of lithium upon mood swings is controlled, at least in part, by catecholaminergic systems in the brain. The interrelationship between brain catecholamines and thyroid hormones seems to be important to our understanding of the action of lithium in affective illness.
自出生起每日给予大鼠L-三碘甲状腺原氨酸，持续30天，可诱导新生大鼠甲状腺功能亢进，导致其活动能力显著增强，且脑去甲肾上腺素和多巴胺的代谢加快。而给正常大鼠腹腔注射碳酸锂（60毫克/千克），持续6天，对其自发运动活动没有影响，但会增加几个脑区中这种单胺的合成，并可能增加其释放，这种抗躁狂药物可拮抗L-三碘甲状腺原氨酸刺激引起的活动能力增加，以及下丘脑、中脑、纹状体和大脑皮层中去甲肾上腺素和多巴胺的代谢增加。此外，锂治疗可使年轻的甲状腺功能亢进大鼠的儿茶酚-O-甲基转移酶（EC 2.1.1.6）活性恢复到几乎正常的水平。我们的数据表明，锂对情绪波动的反相或抑制作用至少部分受脑中儿茶酚胺能系统的控制。脑儿茶酚胺与甲状腺激素之间的相互关系似乎对我们理解锂在情感性疾病中的作用很重要。
