Riby L M, Marriott A, Bullock R, Hancock J, Smallwood J, McLaughlin J
Division of Psychology, Northumbria University, Newcastle upon Tyne, Newcastle, UK.
Eur J Clin Nutr. 2009 Apr;63(4):566-71. doi: 10.1038/sj.ejcn.1602981. Epub 2008 Feb 13.
BACKGROUND/OBJECTIVES: Previous research investigating the impact of glucose ingestion and/or improvements in glucose regulation has found selective cognitive facilitation on episodic memory tasks in successful ageing and dementia. The present study aimed to extend this research to mild cognitive impairment (MCI).
SUBJECTS/METHODS: In a repeated-measures design, 24 older adults with and 24 older adults without MCI performed a battery of memory and attention tasks after 25 g of glucose or a sweetness matched placebo. In addition, to assess the impact of individual differences in glucose regulation, blood glucose measurements were taken throughout the testing session.
Consistent with previous research, cognitive facilitation was observed for episodic memory tasks only in both successful ageing and MCI. Older adults with MCI had a similar glucose regulatory response as controls but their fasting levels were elevated. Notably, higher levels of blood glucose were associated with impaired memory performance in both the glucose and placebo conditions. Importantly, both blood glucose and memory performance indices were significant predictors of MCI status.
The utility of glucose supplementation and the use of glucose regulation as a biological marker are discussed in relation to these data.
背景/目的：先前关于摄入葡萄糖和/或改善葡萄糖调节的影响的研究发现，成功老龄化和痴呆症患者在情景记忆任务上存在选择性认知促进作用。本研究旨在将这一研究扩展至轻度认知障碍（MCI）。
受试者/方法：采用重复测量设计，24名患有MCI的老年人和24名未患MCI的老年人在摄入25克葡萄糖或甜度匹配的安慰剂后，进行了一系列记忆和注意力任务。此外，为评估葡萄糖调节个体差异的影响，在整个测试过程中进行了血糖测量。
与先前研究一致，仅在成功老龄化和MCI患者的情景记忆任务中观察到认知促进作用。患有MCI的老年人与对照组的葡萄糖调节反应相似，但他们的空腹血糖水平升高。值得注意的是，在葡萄糖和安慰剂条件下，较高的血糖水平均与记忆表现受损相关。重要的是，血糖和记忆表现指标均是MCI状态的重要预测因素。
结合这些数据讨论了补充葡萄糖的效用以及将葡萄糖调节用作生物标志物的情况。
