Yang Ling, Wu Ying, Li Huaixin, Yu Zhijie, Li Xin, Liu Yong, Lin Xu, Chen Yan
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, China.
Eur J Hum Genet. 2008 Jun;16(6):759-61. doi: 10.1038/ejhg.2008.8. Epub 2008 Feb 13.
Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10 kb upstream of the INSIG2 gene. We analyzed rs7566605 polymorphism in 3125 Chinese in a cross-sectional study. We found no significant association of rs7566605 polymorphism with body mass index (BMI) and waist circumference among all participants (P=0.52). However, if geographic location is considered, the C/C genotype of rs7566605 was marginally associated with increased levels of BMI and risk of obesity among individuals living in Shanghai (P=0.06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings.
赫伯特等人报告称，在胰岛素诱导基因2（INSIG2）基因上游10 kb处的常见DNA变异rs7566605与肥胖有关联。我们在一项横断面研究中分析了3125名中国人的rs7566605多态性。我们发现，在所有参与者中，rs7566605多态性与体重指数（BMI）和腰围之间无显著关联（P = 0.52）。然而，如果考虑地理位置，rs7566605的C/C基因型与居住在上海的个体中BMI水平升高及肥胖风险呈边缘性关联（P = 0.06），这表明在特定环境背景下，C/C基因型可能在中国的某些亚人群中导致肥胖。
