Wu Ann Chen, Gillman Matthew W, Taveras Elsie M, Litonjua Augusto A
Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts, U.S.A.
Clin Med Pediatr. 2009;3:33-37. doi: 10.4137/cmped.s2279.
Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11-60 years.1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.
研究人员已描述了位于胰岛素诱导基因2（INSIG2）附近的常见DNA多态性rs7566605与多个独立人群肥胖之间的关联，这些人群包括11至60岁的受试者。据我们所知，尚无研究探讨这种多态性与幼儿期体重状况之间的关联。我们在参与“活力计划”（一项出生前队列研究）的319名6个月和3岁儿童中，探究了rs7566605多态性与身长体重比之间的关联。与对年龄较大个体的研究不同，与GG纯合子或GC杂合子相比，CC纯合子与出生至6个月龄之间身长体重比z评分的较低增长相关。在3岁时，我们未发现关联。INSIG2基因与肥胖的关联可能会随年龄而改变方向。
