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一种常见的多态性与维吾尔族人群的体重指数相关。

A common polymorphism is associated with body mass index in Uyghur population.

作者信息

Zhang Jun, Lin Rong, Wang Fen, Lu Ming, Lin Ren-yong, Wang Shi-zhen, Wen Hao, Jin Li, Wang Xiao-feng

机构信息

MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

出版信息

Diabetes Res Clin Pract. 2008 Aug;81(2):e11-3. doi: 10.1016/j.diabres.2008.03.022. Epub 2008 Jun 2.

DOI:10.1016/j.diabres.2008.03.022
PMID:18514965
Abstract

We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population. We observed a significant association of rs7566605 polymorphism with BMI related obesity in Uyghurs with an odds ratio of 1.47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age.

摘要

在一项针对维吾尔族人群的基于人群的关联研究中，我们旨在观察胰岛素诱导基因2（INSIG2）基因附近的一个常见基因变异（rs7655505）与体重指数（BMI）相关肥胖之间的关联。在显性模型（CC + GC 对比 GG）下，我们观察到维吾尔族中rs7566605多态性与BMI相关肥胖存在显著关联，优势比为1.47（95%置信区间1.11 - 1.95，P = 0.006）。无论性别和年龄，rs7566605 CC + GC的平均BMI比GG基因型高0.59kg/m²（P = 0.024）。

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