Friedenberg Frank K, Desipio Joshua, Korimilli Annapurna, Bohning Matthew, Sum Eva, Parkman Henry P, Richter Joel E, Fisher Robert S
Department of Medicine, Section of Gastroenterology, Temple University Hospital, Temple University School of Medicine, 3401 N. Broad Street, Philadelphia, PA 19140, USA.
Dig Dis Sci. 2008 Apr;53(4):905-11. doi: 10.1007/s10620-008-0214-1. Epub 2008 Feb 13.
The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide.
Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 microg kg(-1) h(-1).
Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 +/- 2.1 to 9.9 +/- 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 microg kg(-1) h(-1) dose increased tonic pressure (8.8 +/- 1.4 to 17.6 +/- 2.0 mmHg; P = 0.01) as compared with the 0.02 microg kg(-1) h(-1) dose (4.7 +/- 0.7 to 7.3 +/- 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 +/- 28.4 mmHg and their frequency was 4.9 +/- 1.1 contractions min(-1).
CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 mug kg(-1) h(-1) is greater than the response to 0.02 mug kg(-1) h(-1).
本研究的目的是确定高分辨率固态导管系统能否检测到胃窦和幽门内的局部压力变化对胆囊收缩素八肽的反应。
受试者以0.02或0.06微克/千克（-1）小时（-1）的剂量接受30分钟的胆囊收缩素八肽输注。
研究了5名男性和2名女性。输注后，I期移行性复合运动期间的平均胃窦压力从5.3±2.1毫米汞柱增加到9.9±2.4毫米汞柱（P = 0.028）。在幽门处，与0.02微克/千克（-1）小时（-1）的剂量（4.7±0.7至7.3±0.4毫米汞柱；P =无显著性差异）相比，只有0.06微克/千克（-1）小时（-1）的剂量增加了紧张性压力（8.8±1.4至17.6±2.0毫米汞柱；P = 0.01）。幽门相性压力波的峰值压力为153±28.4毫米汞柱，其频率为4.9±1.1次收缩/分钟（-1）。
胆囊收缩素八肽可引起幽门括约肌的紧张性和相性活动。0.06微克/千克（-1）小时（-1）剂量的收缩反应大于0.02微克/千克（-1）小时（-1）剂量的反应。
