胃残端癌风险的地理差异：日本不存在风险增加的情况？
Geographical variance in the risk of gastric stump cancer: no increased risk in Japan?
作者信息
Tersmette A C, Giardiello F M, Offerhaus G J, Tersmette K W, Ohara K, Vandenbroucke J P, Tytgat G N
机构信息
Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands.
出版信息
Jpn J Cancer Res. 1991 Mar;82(3):266-72. doi: 10.1111/j.1349-7006.1991.tb01841.x.
Geographical differences may exist in the risk of gastric stump cancer. Therefore, we performed meta-analysis of literature reports in Japan (n = 3), the USA (n = 4), and Europe (n = 20) on the risk of postgastrectomy cancer. The weighted mean relative risk of stump cancer in Japan was 0.28, 95% confidence limits 0.21-0.38 as compared to 1.53, 95% confidence limits 0.98-2.41 in the USA and 1.66, 95% confidence limits 1.55-1.79 in Europe. Thus, the risk of gastric cancer in the post-gastrectomy patient seems decreased in Japan and is significantly less than in the USA or Europe, where an increased risk exists. Since there is a high risk of gastric cancer of the intact stomach in Japan, the discovery of a low cancer risk in the gastric stump may provide evidence that these gastric cancers are two different entities.
胃残端癌的风险可能存在地域差异。因此，我们对日本（n = 3）、美国（n = 4）和欧洲（n = 20）关于胃切除术后癌症风险的文献报告进行了荟萃分析。日本残端癌的加权平均相对风险为0.28，95%置信区间为0.21 - 0.38，而美国为1.53，95%置信区间为0.98 - 2.41，欧洲为1.66，95%置信区间为1.55 - 1.79。因此，在日本胃切除术后患者患胃癌的风险似乎降低了，且明显低于美国或欧洲，在美国和欧洲存在风险增加的情况。由于在日本完整胃患胃癌的风险较高，胃残端癌症风险较低这一发现可能提供证据表明这些胃癌是两种不同的实体。
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