健康男性唾液和血清中游离前列腺特异性抗原与总前列腺特异性抗原的比率以及总前列腺特异性抗原与蛋白质浓度的比率。

Ratios of free to total prostate-specific antigen and total prostate specific antigen to protein concentrations in saliva and serum of healthy men.

作者信息

Ayatollahi Hossein, Darabi Mahboub Mohammad Reza, Mohammadian Nema, Parizadeh Mohammad Reza, Kianoosh Tayyebeh, Khabbaz Khoob Mahdi, Kamalian Fahimeh

机构信息

Department of Biochemistry and Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Urol J. 2007 Fall;4(4):238-41.

PMID:18270950

Abstract

INTRODUCTION

We evaluated the ratio of free to total prostate-specific antigen (PSA) and PSA to protein concentrations in saliva and serum of healthy men.

MATERIALS AND METHODS

Concentrations of protein, free PSA, and total PSA in serum and saliva were measured in 30 healthy men aged 42 to 73 years, and their ratios were compared between the two fluids.

RESULTS

There was a significant direct correlation between serum free-total PSA ratios of serum and saliva (P = .04) and between total PSA-protein ratios of serum and saliva (P = .02). Also, there were significant correlations between total and free PSA levels in saliva (P = .05) and between those in serum (P < .001). Significant inverse and direct correlations were detected between the body mass index and serum values of total PSA-protein (P = .04) and free-total PSA (P = .01), respectively.

CONCLUSION

We can use saliva sample instead of serum sample for estimation of free-total PSA and total PSA-protein levels in men without prostate diseases. There is, however, a pressing need for much additional research in this area before the true clinical value of saliva as a diagnostic fluid can be determined.

摘要

引言

我们评估了健康男性唾液和血清中游离前列腺特异性抗原（PSA）与总PSA的比率以及PSA与蛋白质浓度的比率。

材料与方法

对30名年龄在42至73岁的健康男性的血清和唾液中的蛋白质、游离PSA和总PSA浓度进行了测量，并比较了两种液体之间的比率。

结果

血清和唾液中血清游离总PSA比率之间（P = .04）以及血清和唾液中总PSA - 蛋白质比率之间（P = .02）存在显著的正相关。此外，唾液中总PSA和游离PSA水平之间（P = .05）以及血清中总PSA和游离PSA水平之间（P < .001）存在显著相关性。体重指数与血清总PSA - 蛋白质值（P = .04）和游离总PSA值（P = .01）之间分别检测到显著的负相关和正相关。