Korda Michelle, Blunn Gordon, Goodship Allen, Hua Jia
Centre for Biomedical Engineering, Institute of Orthopaedics and Musculo-Skeletal Science, University College London, Royal National Orthopaedic Hospital Trust, Brockley Hill, Stanmore, Middlesex HA7 4LP, United Kingdom.
J Orthop Res. 2008 Jun;26(6):880-5. doi: 10.1002/jor.20598.
Tissue engineering approaches to regenerate bone stock in revision total hip replacements could enhance the longevity of the implant and benefit the quality of the patient's life. This study investigated the impaction of allograft with mesenchymal stem cells in an ovine hip hemiarthroplasty model. In total, 10 sheep were divided into two groups with 5 sheep in each group. The groups were: 1) mesenchymal stem cells mixed with allograft; 2) allograft only as a control. Ground reaction force was assessed for limb function and showed that there was no significant difference in the recovery for animals in different groups. The amount of bone regenerated around the hip replacement was assessed using un-decalcified histology. The results showed that the stem cell group generated significantly more new bone at the implant-allograft interface and within the graft than the control group. The results from this study indicate that the use of stem cells on an allograft scaffold increases bone formation indicating that the use of stem cells for revision hip arthroplasty may be beneficial for patients undergoing revision surgery where the bone stock is compromised.
在翻修全髋关节置换术中采用组织工程方法再生骨储备可提高植入物的使用寿命，并改善患者的生活质量。本研究在绵羊半髋关节置换模型中研究了同种异体移植物与间充质干细胞的作用。总共10只绵羊被分为两组，每组5只。分组如下：1）间充质干细胞与同种异体移植物混合；2）仅同种异体移植物作为对照。评估地面反作用力以了解肢体功能，结果显示不同组动物的恢复情况无显著差异。使用未脱钙组织学评估髋关节置换周围再生的骨量。结果表明，与对照组相比，干细胞组在植入物-同种异体移植物界面和移植物内产生的新骨明显更多。本研究结果表明，在同种异体移植物支架上使用干细胞可增加骨形成，这表明在骨储备受损的翻修手术中，使用干细胞进行髋关节翻修术可能对患者有益。
