Drbalová K, Matucha P, Matějková-Běhanová M, Bílek R, Kříž L, Kazihnitková H, Hampl R
Institute of Endocrinology, Prague, Czech Republic.
Physiol Res. 2008;57 Suppl 1:S119-S125. doi: 10.33549/physiolres.931496. Epub 2008 Feb 13.
Immunomodulatory steroids, dehydroepiandrosterone and its 7-hydroxylated metabolites and sex hormone-binding globulin (SHBG) were determined in sera of 88 women aged 18-75 years. The group consisted of 34 healthy women, 37 women with subclinical and 17 women with manifest hypothyroidism. In all subjects the laboratory parameters of thyroid function (thyrotropin, free thyroxine and triiodothyronine) and thyroid autoantibodies to thyroid peroxidase and thyroglobulin were determined. The aim was to find out 1) whether the above steroids and SHBG levels differ in individual groups according to thyroid status, 2) whether correlations exist among investigated steroids and thyroid laboratory parameters, and 3) whether the respective steroid and SHBG levels differ according to the presence of principal thyroid autoantibodies. With the exception of 7beta-hydroxy-dehydroepindrosterone levels, which were decreased in patients with manifest hypothyroidism (p<0.05), no significant differences in steroid and SHBG levels among groups according to diagnosis were found. On the other hand, significantly decreased levels of all the immunomodulatory steroids studied were found in subjects with positive titres of thyroid autoantibodies. This finding was supported by a tight negative correlation among the above steroids and thyroid autoantibodies. In addition, these steroids correlated negatively with thyrotropin and positively with free thyroid hormones. The results point to a negative relationship between the above mentioned immunoprotective steroids and the extent of the autoimmune process in hypothyroidism.
在88名年龄在18至75岁的女性血清中测定了免疫调节类固醇、脱氢表雄酮及其7-羟基化代谢产物和性激素结合球蛋白（SHBG）。该组包括34名健康女性、37名亚临床女性和17名显性甲状腺功能减退女性。对所有受试者测定了甲状腺功能的实验室参数（促甲状腺激素、游离甲状腺素和三碘甲状腺原氨酸）以及甲状腺过氧化物酶和甲状腺球蛋白的甲状腺自身抗体。目的是找出：1）上述类固醇和SHBG水平是否根据甲状腺状态在各个组中有所不同；2）所研究的类固醇与甲状腺实验室参数之间是否存在相关性；3）相应的类固醇和SHBG水平是否根据主要甲状腺自身抗体的存在而有所不同。除显性甲状腺功能减退患者的7β-羟基脱氢表雄酮水平降低外（p<0.05），根据诊断分组，各组之间的类固醇和SHBG水平无显著差异。另一方面，在甲状腺自身抗体滴度呈阳性的受试者中，发现所有研究的免疫调节类固醇水平均显著降低。上述类固醇与甲状腺自身抗体之间紧密的负相关支持了这一发现。此外，这些类固醇与促甲状腺激素呈负相关，与游离甲状腺激素呈正相关。结果表明上述免疫保护类固醇与甲状腺功能减退症自身免疫过程的程度之间存在负相关关系。
