Wakabayashi Toshiteru, Yoshizawa Yuusuke, Kawana Seiji
Department of Dermatology, Nippon Medical School, Tokyo, Japan.
J Dermatol. 2008 Feb;35(2):111-4. doi: 10.1111/j.1346-8138.2008.00425.x.
We report an 81-year-old male with cholesterol crystal embolization (CCE). He had been treated with warfarin for atrial fibrillation and an old cerebral infarction but had recurrence of cerebral infarction after warfarin was discontinued as treatment of CCE. Anticoagulation therapy by heparin in addition to warfarin was restarted, with the result that symptoms of cerebral ischemic damage did not recur and skin manifestations of CCE rapidly improved. These results suggest the possibility that heparin may be effective in the treatment of CCE, because CCE is not the result of pure embolization by cholesterol crystals but is a result of a combination with simultaneous thrombi.
我们报告一例81岁患有胆固醇结晶栓塞（CCE）的男性患者。他曾因心房颤动和陈旧性脑梗死接受华法林治疗，但在停用华法林作为CCE的治疗后发生了脑梗死复发。除华法林外，重新开始使用肝素进行抗凝治疗，结果脑缺血损伤症状未再复发，CCE的皮肤表现迅速改善。这些结果提示肝素可能对CCE治疗有效，因为CCE并非单纯由胆固醇结晶栓塞所致，而是同时合并血栓形成的结果。
