Moshiri Esmail, Basti Afshin Akhondzadeh, Noorbala Ahamad-Ali, Jamshidi Amir-Hossein, Hesameddin Abbasi Seyed, Akhondzadeh Shahin
Department of Anesthesiology, Arak University of Medical Sciences, Arak, and Pychiatric Research Center, Roozbeh Hospital, Tehran, Iran.
Phytomedicine. 2006 Nov;13(9-10):607-11. doi: 10.1016/j.phymed.2006.08.006. Epub 2006 Sep 18.
Depression is a major worldwide health problem. Indeed, by 2020, depressive disorders are estimated to represent the second largest disease burden worldwide. Although a variety of pharmaceutical agents are available for the treatment of depression, psychiatrists find that many patients cannot tolerate the side effects, do not respond adequately, or finally lose their response. Our objective was to assess the efficacy of petal of Crocus sativus in the treatment of mild-to-moderate depression in a 6-week double-blind, placebo-controlled and randomized trial. Forty adult outpatients who met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition for major depression based on the structured clinical interview for DSM IV participated in the trial. In this double-blind, placebo-controlled and randomized trial, patients were randomly assigned to receive capsule of petal of C. sativus 30 mg/day (BD) (Group 1) and capsule of placebo (BD) (Group 2) for a 6-week study. At 6 weeks, petal of C. sativus produced a significantly better outcome on Hamilton Depression Rating Scale than placebo (d.f.=1, F=16.87, p<0.001). There were no significant differences in the two groups in terms of observed side effects. The results of this study indicate the efficacy of petal of C. sativus in the treatment of mild-to-moderate depression. A large-scale trial is justified.
抑郁症是一个全球性的重大健康问题。事实上，据估计到2020年，抑郁症将成为全球第二大疾病负担。尽管有多种药物可用于治疗抑郁症，但精神科医生发现许多患者无法耐受副作用、反应不佳或最终失去疗效。我们的目的是在一项为期6周的双盲、安慰剂对照随机试验中评估藏红花花瓣治疗轻至中度抑郁症的疗效。40名成年门诊患者根据《精神障碍诊断与统计手册》第四版，通过DSM-IV结构化临床访谈确诊为重度抑郁症，参与了该试验。在这项双盲、安慰剂对照随机试验中，患者被随机分配接受30毫克/天（每日两次）的藏红花花瓣胶囊（第1组）和安慰剂胶囊（每日两次）（第2组），进行为期6周的研究。6周时，藏红花花瓣在汉密尔顿抑郁量表上的疗效显著优于安慰剂（自由度=1，F=16.87，p<0.001）。两组观察到的副作用没有显著差异。本研究结果表明藏红花花瓣治疗轻至中度抑郁症有效。有必要进行大规模试验。
