Micro/Nano Bioengineering Lab, Department of Biological and Agricultural Engineering, The University of Georgia, Athens, GA 30602,
J Biol Eng. 2007 Oct 10;1:5. doi: 10.1186/1754-1611-1-5.
The use of nanopillar array electrodes (NAEs) for biosensor applications was explored using a combined experimental and simulation approach to characterize the role of reaction kinetics and mass transport in glucose detection with NAEs. Thin gold electrodes with arrays of vertically standing gold nanopillars were fabricated and their amperometric current responses were measured under bare and functionalized conditions. Results show that the sensing performances of both the bare and functionalized NAEs were affected not only by the presence and variation of the nanoscale structures on the electrodes but also by the reaction kinetics and mass transport of the analyte species involved. These results will shed new light for enhancing the performance of nanostructure based biosensors.
采用实验与模拟相结合的方法研究了纳米柱阵列电极（NAE）在生物传感器中的应用，以表征反应动力学和质量传递在 NAEs 葡萄糖检测中的作用。制备了具有垂直排列金纳米柱阵列的薄金电极，并在裸电极和功能化条件下测量了它们的安培电流响应。结果表明，裸电极和功能化 NAE 的传感性能不仅受到电极上纳米结构的存在和变化的影响，还受到分析物物种的反应动力学和质量传递的影响。这些结果将为提高基于纳米结构的生物传感器的性能提供新的思路。
