临床试验中的脑肿瘤成像
Brain tumor imaging in clinical trials.
作者信息
Henson J W, Ulmer S, Harris G J
机构信息
Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
AJNR Am J Neuroradiol. 2008 Mar;29(3):419-24. doi: 10.3174/ajnr.A0963. Epub 2008 Feb 13.
Abstract
There are substantial challenges in the radiologic evaluation of tumor size during clinical trials, and it is important for neuroradiologists to have a firm understanding of these issues. This review will examine measurement approaches, response criteria, selection of lesions for measurement, technical imaging considerations, interval between tumor measurements and response confirmation, and validity of imaging as a measure of efficacy.
摘要
在临床试验中，肿瘤大小的放射学评估存在诸多重大挑战，神经放射科医生深入了解这些问题非常重要。本综述将探讨测量方法、反应标准、测量病变的选择、成像技术考量、肿瘤测量与反应确认之间的间隔以及成像作为疗效衡量指标的有效性。
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