生殖器溃疡会促使在经阴道接种细胞相关的猿猴免疫缺陷病毒SIVmac239后病毒快速进入并扩散。
Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239.
作者信息
Weiler Andrea M, Li Qingsheng, Duan Lijie, Kaizu Masahiko, Weisgrau Kim L, Friedrich Thomas C, Reynolds Matthew R, Haase Ashley T, Rakasz Eva G
机构信息
AIDS Vaccine Laboratory, WNPRC, 555 Science Dr., Madison, WI 53711, USA.
出版信息
J Virol. 2008 Apr;82(8):4154-8. doi: 10.1128/JVI.01947-07. Epub 2008 Feb 13.
Abstract
Here we report the results of studies in the simian immunodeficiency virus (SIV)-rhesus macaque model of intravaginal transmission of human immunodeficiency virus type 1 in the setting of genital ulcerative diseases. We document preferential association of vRNA with induced ulcers during the first days of infection and show that allogeneic cells of the inoculum traffic from the vaginal lumen to lymphatic tissues. This surprisingly rapid systemic dissemination in this cell-associated SIV challenge model thus reveals the challenges of preventing transmission in the setting of genital ulcerative diseases and illustrates the utility of this animal model in tests of strategies aimed at reducing transmission under these conditions.
摘要
在此，我们报告了在恒河猴感染猴免疫缺陷病毒（SIV）模型中，研究1型人类免疫缺陷病毒在生殖器溃疡性疾病背景下经阴道传播的结果。我们记录了感染初期病毒RNA（vRNA）与诱发溃疡的优先关联，并表明接种物中的异体细胞从阴道腔转移至淋巴组织。在这种与细胞相关的SIV攻击模型中，这种惊人的快速全身传播揭示了在生殖器溃疡性疾病背景下预防传播的挑战，并说明了该动物模型在测试旨在减少这些条件下传播的策略中的实用性。
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