Archimbaud E, Guyotat D, Maupas J, Ploton C, Nageotte A, Devaux Y, Thomas X, Fleurette J, Fiere D
Service d'Hématologie, Hôpítal Edouard Herriot, UFR Alexis Carrel, Lyon, France.
Eur J Cancer. 1991;27(2):174-8. doi: 10.1016/0277-5379(91)90481-r.
To test the value of pefloxacin for the prevention of infections in patients with chemotherapy-induced neutropenia, oral pefloxacin plus vancomycin (PV) (n = 76) or gentamicin, colistin sulphate and vancomycin (GCV) (n = 74) were administered in a randomised double-blind study. Infections were significantly less severe in the PV than in the GCV group. Patients receiving PV had significantly fewer episodes of bacteraemia and central venous line infections than patients treated with GCV. Gram-positive and gram-negative infections were significantly less frequent in patients receiving PV, because of fewer infections with Staphylococcus species and enterobacteriaceae. Stool culture detected significantly more gram-positive organisms in the PV group and more gram-negative organisms in the GCV group. Thus, PV was more efficacious than GCV for the prevention of gram-positive and gram-negative infections in the neutropenic patients, despite lower efficacy in eradicating gram-positive organisms from the lower intestinal tract.
为了测试培氟沙星在预防化疗引起的中性粒细胞减少患者感染中的价值，在一项随机双盲研究中，对口服培氟沙星加万古霉素（PV）组（n = 76）或庆大霉素、硫酸多粘菌素和万古霉素（GCV）组（n = 74）进行了给药。PV组感染的严重程度明显低于GCV组。接受PV治疗的患者发生菌血症和中心静脉导管感染的次数明显少于接受GCV治疗的患者。由于葡萄球菌属和肠杆菌科感染较少，接受PV治疗的患者革兰氏阳性和革兰氏阴性感染的发生率明显较低。粪便培养在PV组中检测到的革兰氏阳性菌明显更多，在GCV组中检测到的革兰氏阴性菌更多。因此，尽管PV在清除下消化道革兰氏阳性菌方面效果较低，但在预防中性粒细胞减少患者的革兰氏阳性和革兰氏阴性感染方面比GCV更有效。
