De Jager P L, Simon K C, Munger K L, Rioux J D, Hafler D A, Ascherio A
Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Neurology. 2008 Mar 25;70(13 Pt 2):1113-8. doi: 10.1212/01.wnl.0000294325.63006.f8. Epub 2008 Feb 13.
Individuals with high levels of antibodies to the Epstein-Barr virus nuclear antigen 1 (EBNA-1) have an increased risk of developing multiple sclerosis (MS), but this association could be confounded by genetic susceptibility.
We conducted a nested case-control study including 148 women with MS (18 with blood collected before disease onset) and 296 age-matched healthy women to determine whether the human leukocyte antigen (HLA) DRB1*1501 allele (DR15) and anti-Epstein-Barr virus (anti-EBV) antibody titers are independent risk factors for MS.
The association between anti-EBNA-1 antibody titers and MS risk was not affected by adjustment for DR15 and was similar in DR15-positive and DR15-negative women. The relative risk of MS among DR15-positive women with elevated (>1:320) anti-EBNA-1 titers was ninefold higher than that of DR15-negative women with low (<1:80) anti-EBNA-1 titers.
Anti-Epstein-Barr virus nuclear antigen 1 (anti-EBNA-1) antibody titers are a risk factor for multiple sclerosis (MS), independently from the DR15 allele. Carriers of the DR15 allele with elevated anti-EBNA-1 antibody titers may have a markedly increased risk of MS.
抗EB病毒核抗原1（EBNA-1）抗体水平高的个体患多发性硬化症（MS）的风险增加，但这种关联可能会受到遗传易感性的混淆。
我们进行了一项巢式病例对照研究，纳入了148例MS女性患者（其中18例在疾病发作前采集了血液样本）和296例年龄匹配的健康女性，以确定人类白细胞抗原（HLA）DRB1*1501等位基因（DR15）和抗EB病毒（anti-EBV）抗体滴度是否为MS的独立危险因素。
调整DR15后，抗EBNA-1抗体滴度与MS风险之间的关联不受影响，在DR15阳性和DR15阴性女性中相似。抗EBNA-1滴度升高（>1:320）的DR15阳性女性患MS的相对风险比抗EBNA-1滴度低（<1:80）的DR15阴性女性高9倍。
抗EB病毒核抗原1（anti-EBNA-1）抗体滴度是多发性硬化症（MS）的一个危险因素，独立于DR15等位基因。抗EBNA-1抗体滴度升高的DR15等位基因携带者患MS的风险可能显著增加。
