Solares Sandra, León Javier, García-Gutiérrez Lucía
Instituto de Biomedicina y Biotecnología de Cantabria, Departamento de Biología Molecular, Universidad de Cantabria-CSIC, Albert Einstein 22, 39011 Cantabria, Spain.
Cancers (Basel). 2024 Dec 18;16(24):4212. doi: 10.3390/cancers16244212.
The Epstein-Barr virus (EBV) is associated with a wide range of diseases, malignant and non-malignant. EBV was, in fact, the first virus described with cell transformation capacity, discovered by Epstein in 1964 in lymphoma samples from African children. Since then, EBV has been associated with several human tumors including nasopharyngeal carcinoma, gastric carcinoma, T-cell lymphoma, Hodgkin lymphoma, diffuse large B cell lymphoma, and Burkitt lymphoma among others. The molecular hallmark of Burkitt lymphoma (BL) is a chromosomal translocation that involves the gene and immunoglobulin loci, resulting in the deregulated expression of , an oncogenic transcription factor that appears deregulated in about half of human tumors. The role of MYC in lymphoma is well established, as MYC overexpression drives B cell proliferation through multiple mechanisms, foremost, the stimulation of the cell cycle. Indeed, MYC is found overexpressed or deregulated in several non-Hodgkin lymphomas. Most endemic and many sporadic BLs are associated with EBV infection. While some mechanisms by which EBV can contribute to BL have been reported, the mechanism that links translocation and EBV infection in BL is still under debate. Here, we review the main EBV-associated diseases, with a special focus on BL, and we discuss the interaction of EBV and translocation during B cell malignant transformation in BL.
爱泼斯坦-巴尔病毒（EBV）与多种疾病相关，包括恶性和非恶性疾病。事实上，EBV是1964年由爱泼斯坦在非洲儿童淋巴瘤样本中发现的第一种具有细胞转化能力的病毒。从那时起，EBV就与多种人类肿瘤相关，包括鼻咽癌、胃癌、T细胞淋巴瘤、霍奇金淋巴瘤、弥漫性大B细胞淋巴瘤和伯基特淋巴瘤等。伯基特淋巴瘤（BL）的分子特征是一种染色体易位，涉及 基因和免疫球蛋白基因座，导致 （一种致癌转录因子）的表达失调，该因子在大约一半的人类肿瘤中似乎表达失调。MYC在淋巴瘤中的作用已得到充分证实，因为MYC的过表达通过多种机制驱动B细胞增殖，其中最重要的是刺激细胞周期。事实上，在几种非霍奇金淋巴瘤中发现MYC过表达或失调。大多数地方性和许多散发性BL与EBV感染有关。虽然已经报道了EBV导致BL的一些机制，但BL中连接 易位和EBV感染的机制仍在争论中。在这里，我们综述了主要的EBV相关疾病，特别关注BL，并讨论了BL中B细胞恶性转化过程中EBV与 易位的相互作用。
