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脊髓前角中 5-羟色胺和色氨酸羟化酶表达的变化。

Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord.

机构信息

Institute of Healthy and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.

出版信息

Neurosci Bull. 2008 Feb;24(1):29-33. doi: 10.1007/s12264-008-1031-4.

DOI:10.1007/s12264-008-1031-4
PMID:18273073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5552521/
Abstract

OBJECTIVE

To investigate changes of 5-hydroxytryptamine (5-HT) and its synthesis rate-limiting enzyme tryptophan hydroxylase (TPH) in the ventral horn of spinal cord after exercise-induced fatigue, and to further discuss the mechanism of exercise-induced central fatigue at spinal level.

METHODS

Sixteen healthy adult Wistar rats were randomly divided into 2 groups: exercise-induced fatigue group and control group. Immunohistochemical staining for 5-HT and TPH in the ventral horn were performed and analyzed quantitatively. The mean optic densities of 5-HT and TPH positive fibers or terminals were measured by computerized image analyzer.

RESULTS

Both 5-HT and TPH positive fibers/terminals decreased in the exercise-induced fatigue group. The immunohistochemical staining was weaker and the mean optic densities decreased obviously in the fatigue group compared with those in the control group (P< 0.05).

CONCLUSION

5-HT and TPH in the ventral horn of spinal cord might be involved in exercise-induced fatigue.

摘要

目的

探讨运动性疲劳后脊髓腹角 5-羟色胺（5-HT）及其合成限速酶色氨酸羟化酶（TPH）的变化，进一步探讨运动性中枢疲劳的脊髓机制。

方法

将 16 只健康成年 Wistar 大鼠随机分为运动性疲劳组和对照组。采用免疫组织化学染色法检测脊髓腹角 5-HT 和 TPH，并进行定量分析。用计算机图像分析系统测量 5-HT 和 TPH 阳性纤维或终末的平均光密度。

结果

运动性疲劳组中 5-HT 和 TPH 阳性纤维/终末均减少。与对照组相比，疲劳组免疫组织化学染色较弱，平均光密度明显降低（P<0.05）。

结论

脊髓腹角 5-HT 和 TPH 可能参与了运动性疲劳的发生。

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