Losikoff Phyllis, Fichorova Raina, Snyder Brad, Rodriguez Irma, Cu-Uvin Susan, Harwell Joseph, Mayer Kenneth H
Department of Pediatrics, Division of Infectious Diseases, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
Infect Dis Obstet Gynecol. 2007;2007:92307. doi: 10.1155/2007/92307.
Genital tract infections and cytokine perturbations are associated with increased HIV acquisition and transmission. We measured the relationship between bacterial vaginosis (BV) and concentrations of Interleukin-8 (IL-8), Interleukin-1beta (IL-1beta), and Interleukin-6 (IL-6) in cervicovaginal lavage (CVL) specimens collected longitudinally from 16 HIV-infected and 8 HIV-uninfected high-risk women. CVL samples were analyzed when women presented with BV, and at their next visit, after successful treatment, when BV was cleared. A subset of participants had cytokine levels evaluated at three consecutive clinic visits: before developing BV, at the time of BV diagnosis, and after clearing BV. Significantly higher IL-8, but not IL-1beta or IL-6 levels were present when women had active BV compared to when BV was absent. Trends in cytokine levels were similar for HIV-infected and HIV-uninfected women. BV in these women was associated with significantly higher concentrations of genital tract IL-8 which decreased 2.4 fold when BV was cleared.
生殖道感染和细胞因子紊乱与艾滋病毒感染和传播增加有关。我们测量了16名感染艾滋病毒和8名未感染艾滋病毒的高危女性纵向收集的宫颈阴道灌洗（CVL）样本中细菌性阴道病（BV）与白细胞介素-8（IL-8）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）浓度之间的关系。当女性出现BV时以及在成功治疗BV清除后的下一次就诊时对CVL样本进行分析。一部分参与者在连续三次门诊就诊时评估细胞因子水平：在发生BV之前、BV诊断时以及BV清除后。与无BV时相比，女性患有活动性BV时IL-8水平显著更高，但IL-1β或IL-6水平并非如此。感染艾滋病毒和未感染艾滋病毒的女性细胞因子水平趋势相似。这些女性的BV与生殖道IL-8浓度显著升高有关，BV清除后IL-8浓度下降2.4倍。
