女性生殖道的黏膜免疫、艾滋病毒/艾滋病
Mucosal immunity in the female genital tract, HIV/AIDS.
作者信息
Reis Machado Juliana, da Silva Marcos Vinícius, Cavellani Camila Lourencini, dos Reis Marlene Antônia, Monteiro Maria Luiza Gonçalves dos Reis, Teixeira Vicente de Paula Antunes, Miranda Corrêa Rosana Rosa
机构信息
Discipline of General Pathology, Nephropathology Service, Federal University of Triangulo Mineiro, Rua Frei Paulino n° 30, Bairro Abadia, 38025-180 Uberaba, MG, Brazil.
Discipline of Immunology, Federal University of Triangulo Mineiro, Rua Frei Paulino n° 30, Bairro Abadia, 38025-180 Uberaba, MG, Brazil.
出版信息
Biomed Res Int. 2014;2014:350195. doi: 10.1155/2014/350195. Epub 2014 Sep 15.
Mucosal immunity consists of innate and adaptive immune responses which can be influenced by systemic immunity. Despite having been the subject of intensive studies, it is not fully elucidated what exactly occurs after HIV contact with the female genital tract mucosa. The sexual route is the main route of HIV transmission, with an increased risk of infection in women compared to men. Several characteristics of the female genital tract make it suitable for inoculation, establishment of infection, and systemic spread of the virus, which causes local changes that may favor the development of infections by other pathogens, often called sexually transmitted diseases (STDs). The relationship of these STDs with HIV infection has been widely studied. Here we review the characteristics of mucosal immunity of the female genital tract, its alterations due to HIV/AIDS, and the characteristics of coinfections between HIV/AIDS and the most prevalent STDs.
黏膜免疫由先天性和适应性免疫反应组成，可受全身免疫的影响。尽管一直是深入研究的主题，但HIV接触女性生殖道黏膜后究竟发生了什么仍未完全阐明。性传播途径是HIV传播的主要途径，女性感染风险高于男性。女性生殖道的几个特征使其适合病毒的接种、感染的建立和全身传播，这会引起局部变化，可能有利于其他病原体感染的发展，这些病原体通常称为性传播疾病（STDs）。这些性传播疾病与HIV感染的关系已得到广泛研究。在此，我们综述女性生殖道黏膜免疫的特征、其因HIV/AIDS导致的改变，以及HIV/AIDS与最常见性传播疾病之间合并感染的特征。
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