Smith Richard, Hicks David, Tomljanovich Paul I, Lele Shashikant B, Rajput Ashwani, Dunn Kelli Bullard
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Am Surg. 2008 Jan;74(1):59-61.
Perianal disease is a common manifestation of Crohn's disease. Rarely malignancy arises in perianal fistulas. The etiology of fistula related cancer remains a subject of debate. We present a unique case of a perianal Crohn's disease with adenomatous epithelialization of a fistula tract and an associated mucinous adenocarcinoma. Our case demonstrates that mucinous adenocarcinoma can arise in long standing perianal Crohn's disease and may be associated with adenomatous transformation of the epithelial lining of the fistula tract.
肛周疾病是克罗恩病的常见表现。肛周瘘管极少发生恶性肿瘤。瘘管相关癌症的病因仍是一个有争议的话题。我们报告了一例独特的肛周克罗恩病病例，其瘘管出现腺瘤样上皮化生，并伴有黏液腺癌。我们的病例表明，黏液腺癌可发生于长期存在的肛周克罗恩病，且可能与瘘管上皮内衬的腺瘤样转化有关。
