Woodall Charles E, Scoggins Charles R, Lewis Angela M, McMasters Kelly M, Martin Robert C G
Department of Surgery, Division of Surgical Oncology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Am Surg. 2008 Jan;74(1):64-8.
Malignant epithelioid hemangioendothelioma is a rare hepatic tumor of vascular origin. It is most commonly found in young to middle aged women, and the tumors vary in reported malignant potential. Compounds such as oral contraceptive pills, poly vinyl chloride, and Thorotrast have been identified as risk factors for subsequent disease development. Radiologic ("lollipop" sign, capsular flattening) and pathologic (Factor-VIII antigen staining positive) evaluation aids in the diagnosis. As with most mesenchymal tumors, surgical resection is the most effective means of controlling local disease and preventing distant metastasis, though adjuvant therapies have been offered for those that are unresectable or not transplant candidates. We present our case of a hepatic malignant epithelioid hemangioendothelioma and a review of the English-language literature.
恶性上皮样血管内皮瘤是一种罕见的起源于血管的肝脏肿瘤。它最常见于年轻至中年女性，并且所报道的肿瘤恶性潜能各不相同。口服避孕药、聚氯乙烯和钍造影剂等化合物已被确定为后续疾病发展的风险因素。放射学检查（“棒棒糖”征、包膜变平）和病理学检查（因子VIII抗原染色阳性）有助于诊断。与大多数间叶组织肿瘤一样，手术切除是控制局部疾病和预防远处转移的最有效方法，不过对于那些无法切除或不适合移植的患者也提供了辅助治疗。我们展示了一例肝脏恶性上皮样血管内皮瘤病例并对英文文献进行了综述。
