Centre of Excellence in e-Medicine, University of Western Australia, Perth, Australia.
Eye (Lond). 2009 Mar;23(3):652-60. doi: 10.1038/eye.2008.11. Epub 2008 Feb 15.
This study compared digital images from a portable slit-lamp camera with 35 mm slit-lamp photographs and traditional ophthalmic assessments in anterior segment disorder's detection.
A total of 196 patients (392 eyes) were recruited from an anterior segment ophthalmology clinic. Each patient underwent an examination by an anterior segment ophthalmologist. Two to three standardized views of 640 x 480 pixels digital images (portable digital slit-lamp camera) and 35 mm photographic slides (Zeiss slit-lamp camera) were taken after the examination. The same ophthalmologist reviewed these images in a masked fashion. Two other masked graders also assessed the digital images. The presence or absence of 33 specific findings was noted at each examination.
Digital images showed moderate to excellent agreement to clinical findings (kappa 0.45-0.82) in areas other than lid pathologies. Lens findings from digital images had moderate to good agreement with the clinical gold standard (unweighted kappa 0.43-0.65, sensitivity 59-77%, specificity 86-94%). Gross cornea signs were well detected with digital images, (kappa 0.72-0.85, sensitivity 67-100%, specificity 98-99). More subtle corneal, conjunctival and lid abnormalities were not identified well. The statistical figures were very similar to the above-mentioned figures when the 35-mm film results were compared to clinical diagnoses. The two image formats showed better agreement when compared to each other than when either is compared with clinical findings.
Diagnoses using digital slit-lamp images were comparable to diagnosis using 35 mm photographic slides for some anterior segment abnormalities.
本研究比较了便携式裂隙灯相机的数字图像与 35mm 裂隙灯照片以及传统眼科评估在前节病变检测中的应用。
从一个前节眼科诊所招募了 196 名患者(392 只眼)。每位患者均由前节眼科医生进行检查。检查后,拍摄 640x480 像素数字图像(便携式数字裂隙灯相机)和 35mm 摄影幻灯片(蔡司裂隙灯相机)的 2 到 3 个标准视图。同一位眼科医生以盲法方式对这些图像进行评估。另外两名盲法评估员也对数字图像进行了评估。每次检查时均记录 33 种特定表现的存在或缺失情况。
数字图像在非眼睑病变区域与临床发现具有中度至高度一致性(kappa 值为 0.45-0.82)。数字图像中的晶状体发现与临床金标准具有中度至良好一致性(未加权 kappa 值为 0.43-0.65,灵敏度为 59-77%,特异性为 86-94%)。数字图像可很好地检测到角膜的大体病变(kappa 值为 0.72-0.85,灵敏度为 67-100%,特异性为 98-99%)。但对更细微的角膜、结膜和眼睑异常则无法很好地识别。当将 35mm 胶片结果与临床诊断进行比较时,这些统计数据与上述数据非常相似。与临床发现相比,这两种图像格式彼此之间的一致性更好。
对于某些前节异常,数字裂隙灯图像的诊断与 35mm 摄影幻灯片的诊断相当。