Xiping Zhang, Hua Tian, Hanqing Chen, Li Chen, Zhiwei Wang, Keyi Wang, Wei Yan, Yun Li, Qingyu Li, Qing He, Fei Wang
Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, Zhejiang Province , China.
Mediators Inflamm. 2007;2007:19469. doi: 10.1155/2007/19469.
To observe the protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with severe acute pancreatitis (SAP).
The SAP rat models were randomly divided into the model group, Baicalin-treated group, Octreotide treated group, and sham operation group. The contents of some inflammatory indexes in blood were determined. The rat mortality, pathological changes of heart, the changes of NF-kappaB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels as well as apoptotic index were observed in all groups, respectively, at 3 hours, 6 hours, and 12 hours after operation.
The survival rate of model group was less than treated groups at 12 hours, difference was significant. The contents of some inflammatory indexes of the treated groups were lower than those of the model group to various degrees at different time points. The pathological myocardial changes under light microscope were milder in treated groups than in model group. The changes of NF-kappaB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels in all groups were different. There was only a case of myocardial cell apoptosis in an Octreotide-treated group at 6 hours.
Baicalin and Octreotide have protecting effects on heart injury of rats with SAP.
观察黄芩苷和奥曲肽对重症急性胰腺炎（SAP）大鼠心脏损伤的保护作用及机制。
将SAP大鼠模型随机分为模型组、黄芩苷治疗组、奥曲肽治疗组和假手术组。测定血液中一些炎症指标的含量。分别在术后3小时、6小时和12小时观察各组大鼠的死亡率、心脏病理变化、NF-κB、P-选择素、Bax、Bcl-2和Caspase-3蛋白表达水平的变化以及凋亡指数。
术后12小时，模型组的存活率低于治疗组，差异有统计学意义。不同时间点，各治疗组的一些炎症指标含量均不同程度低于模型组。治疗组光镜下心肌病理改变较模型组轻。各组NF-κB、P-选择素、Bax、Bcl-2和Caspase-3蛋白表达水平的变化不同。奥曲肽治疗组在6小时时仅出现1例心肌细胞凋亡。
黄芩苷和奥曲肽对SAP大鼠心脏损伤有保护作用。
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