Balestrieri M, Bragagnoli N, Bellantuono C
Servizio di Psicologia Medica, Università di Verona, Italy.
J Affect Disord. 1991 Jan;21(1):45-55. doi: 10.1016/0165-0327(91)90018-n.
We analysed antidepressant drugs (AD) prescription ratios of the GPs working in Verona, Italy, over a 6-year period (1983-1988). The data, provided by a local drug information system (SIF-USL), were calculated as Defined Daily Dose (DDD), which is the unit of drug consumption recommended by WHO. We found that DDD/1000 patients/day increased over the period, mainly because of an increase in the use of 'second-generation' antidepressants and other non-tricyclic antidepressants. An increase in the levels of prescription of AD was observed over the 6 years. This increase was statistically significant when comparing the first (1983) with the other years. Low correlations were found between DDD/patient/year ratios and GPs' age, sex and list size. Harmonic analysis of the seasonal variations in prescriptions of AD revealed a substantial pattern of seasonality, in which the first four harmonics accounted for the greater part (95.5%) of the seasonality. AD prescribing may be linked more closely to seasonal holiday patterns than to seasonality in the onset of depressive disorders.
我们分析了意大利维罗纳的全科医生在1983年至1988年这6年期间的抗抑郁药物（AD）处方率。这些数据由当地药物信息系统（SIF-USL）提供，以限定日剂量（DDD）计算，这是世界卫生组织推荐的药物消费单位。我们发现，在此期间DDD/1000患者/天有所增加，主要是因为“第二代”抗抑郁药和其他非三环类抗抑郁药的使用增加。在这6年中观察到AD处方水平有所上升。将第一年（1983年）与其他年份进行比较时，这种增加具有统计学意义。DDD/患者/年比率与全科医生的年龄、性别和名单规模之间的相关性较低。对AD处方季节性变化的谐波分析揭示了一种显著的季节性模式，其中前四个谐波占季节性的大部分（95.5%）。AD处方可能与季节性节假日模式的联系比与抑郁症发作的季节性联系更为紧密。
