Tansella M, Micciolo R
Servizio di Psicologia Medica, Università di Verona, Italy.
J Affect Disord. 1992 Feb;24(2):117-25. doi: 10.1016/0165-0327(92)90026-3.
Antidepressant drug (AD) prescriptions written in the period 1983-1988 by all GPs working in Verona, Italy were analyzed. The data were provided by a local drug information system and calculated as Defined Daily Dose (DDD). The area was divided in 25 districts, classified on the urban-rural continuum according to population density. Two indices of service provision and two demographic measures were also used in the analysis. An increase in the levels of prescription of AD was observed over the 6 years. No correlation was found between DDD/1000 inhabitants/day rate and population density. This was confirmed using multiple regression analysis, which showed that only the proportion of females in the population was significantly associated with AD prescription. Harmonic analysis of the seasonal variation in prescription showed a moderate degree of seasonality in all districts. When using multiple correlation analysis the seasonality was correlated only with the number of pharmacies available in each district.
对1983年至1988年期间在意大利维罗纳工作的所有全科医生开具的抗抑郁药物（AD）处方进行了分析。数据由当地药物信息系统提供，并以限定日剂量（DDD）计算。该地区分为25个区，根据人口密度在城乡连续体上进行分类。分析中还使用了两项服务提供指标和两项人口统计学指标。在这6年中观察到AD处方水平有所增加。未发现DDD/1000居民/天率与人口密度之间存在相关性。多元回归分析证实了这一点，该分析表明，只有人口中的女性比例与AD处方显著相关。对处方季节性变化的谐波分析表明，所有区都有中等程度的季节性。使用多重相关性分析时，季节性仅与每个区的药房数量相关。
