Arpino C, Da Cas R, Donini G, Pasquini P, Raschetti R, Traversa G
Department of Epidemiology and Biostatistics, National Health Institute, Rome, Italy.
Acta Psychiatr Scand. 1995 Jul;92(1):7-9. doi: 10.1111/j.1600-0447.1995.tb09535.x.
Prescribing patterns of antidepressant drugs were studied, over a period of 30 months, in a random sample of 8743 residents of the area of Rome, Italy. Data from the regional outpatient drug monitoring system were used. The proportion of subjects receiving, during the study period, at least one prescription of antidepressant drugs, was 5.4%; the female-to-male ratio was 2.1. Consumption prevalence increased with age. The single most prescribed drug was fluoxetine followed by amitriptyline and ademetionine. For a surprisingly high proportion of subjects, the observed length of treatment was shorter than expected on the basis of current knowledge in clinical pharmacology. Inappropriate diagnostic and therapeutic procedures are likely explanations.
在30个月的时间里，对意大利罗马地区8743名居民的随机样本进行了抗抑郁药物处方模式的研究。使用了来自地区门诊药物监测系统的数据。在研究期间，接受至少一张抗抑郁药物处方的受试者比例为5.4%；男女比例为2.1。消费患病率随年龄增长而增加。处方量最大的单一药物是氟西汀，其次是阿米替林和腺苷蛋氨酸。对于相当高比例的受试者，观察到的治疗时长比基于临床药理学现有知识预期的要短。诊断和治疗程序不当可能是原因。
