Epstein Joel B
Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois at Chicago, Illinois 60091, USA.
J Can Dent Assoc. 2007 Dec;73(10):953-6.
Advances in the management of HIV infection have resulted in significant changes in survival and in the prevalence and incidence of oral diseases found in persons infected with HIV (as discussed in other articles in this series). HIV is associated with an increased risk of malignant disease that is related to immunosuppression and the activity of the HIV transactivator of transcription protein, coviral infection and exposure to carcinogens. The presence of oral malignancies varies with the route of the transmission of HIV and varies geographically, based on behaviour, viral cofactors, HIV therapy and genetic variation. Oral health care providers can identify these lesions early.
艾滋病毒感染管理方面的进展已导致感染者的生存情况以及口腔疾病的患病率和发病率发生显著变化（本系列的其他文章对此进行了讨论）。艾滋病毒与恶性疾病风险增加相关，这与免疫抑制、艾滋病毒转录激活蛋白的活性、合并病毒感染以及接触致癌物有关。口腔恶性肿瘤的存在因艾滋病毒传播途径而异，并且基于行为、病毒辅助因子、艾滋病毒治疗和基因变异在地理上也有所不同。口腔保健提供者能够早期识别这些病变。
