Rayalam Srujana, Della-Fera Mary Anne, Krieg Paul A, Cox Christopher M, Robins Allan, Baile Clifton A
Department of Animal & Dairy Science, University of Georgia, 444 Animal Science Complex, Athens, GA 30602-2771, USA.
Biochem Biophys Res Commun. 2008 Apr 11;368(3):815-9. doi: 10.1016/j.bbrc.2008.02.008. Epub 2008 Feb 12.
Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.
Apelin是G蛋白偶联受体APJ的内源性配体，已被证明可促进肿瘤血管生成。然而，Apelin对脂肪组织中血管生成的诱导作用尚未得到研究。在本综述中，我们提出Apelin在促进脂肪组织血管生成中可能发挥的作用。我们进一步提出，用抗Apelin抗体阻断Apelin信号通路来靶向脂肪组织血管，不仅会抑制脂肪组织中的血管生成，还会降低肥胖程度。
