Leclercq R, Goulenok C, Loncle-Provot V
Service de Microbiologie, CHU de Caen, Caen, France.
Med Mal Infect. 2008 Mar;38(3):133-40. doi: 10.1016/j.medmal.2007.12.001. Epub 2008 Feb 13.
Tigecycline Evaluation and Surveillance Trial (TEST) is an international surveillance study designed to assess the in vitro activity of tigecycline and 11 comparators against a range of important clinical pathogens from both the community and the hospital. The updated data obtained from the TEST program are integrated in a database server and available with a web application. The website has been designed to disseminate data collected from the international TEST program to the medical community and has been developed to be user-friendly. The use of this program-specific website can be made in a timely manner to extract antimicrobial resistance data of major microorganisms based on chosen selection criteria. This article describes how to use this web-based program for different analyse-types and the multiple options to display search results. Data can be presented in a table or as a graph or diagram, according to the source of the isolate, type of unit, resistance pattern of the pathogen. The website also allows the user to compare the data of antimicrobial testing at a national or regional level. It provides within a few minutes details on the activity of tigecycline and 11 comparators against clinical isolates collected all around the world. Main results of the TEST program on the in vitro activities of tigecyline against more 65,000 clinical isolates throughout the world are presented. The internet gives infectious diseases specialists and microbiologists the opportunity to have immediate access to continuously updated surveillance data. The TEST website should be helpful to clinicians to better select agents in severe infections, particularly for empirical treatment, that is at a time when the choice of the most appropriate antibiotic is essential for the outcome of the patient.
替加环素评估与监测试验(TEST)是一项国际监测研究,旨在评估替加环素及11种对照药物对一系列来自社区和医院的重要临床病原体的体外活性。从TEST项目获得的更新数据整合在一个数据库服务器中,并通过一个网络应用程序提供。该网站旨在将从国际TEST项目收集的数据传播给医学界,并且设计得便于用户使用。可以及时使用这个特定项目的网站,根据选定的选择标准提取主要微生物的抗菌耐药性数据。本文描述了如何使用这个基于网络的程序进行不同类型的分析以及显示搜索结果的多种选项。数据可以根据分离株的来源、单位类型、病原体的耐药模式以表格、图表或示意图的形式呈现。该网站还允许用户在国家或地区层面比较抗菌测试数据。它能在几分钟内提供替加环素及11种对照药物对世界各地收集的临床分离株活性的详细信息。展示了TEST项目关于替加环素对全球超过65000株临床分离株体外活性的主要结果。互联网为传染病专家和微生物学家提供了立即获取持续更新的监测数据的机会。TEST网站应该有助于临床医生在严重感染中更好地选择药物,特别是在经验性治疗时,即在选择最合适的抗生素对患者的治疗结果至关重要的时候。