Thompson P M, Zebrowski G, Neuman R S
Faculty of Medicine, Memorial University, St John's, Newfoundland, Canada.
Neuropharmacology. 1991 Feb;30(2):135-41. doi: 10.1016/0028-3908(91)90196-i.
Noxious stimulation induces cortical desynchronization which in turn can suppress epileptic seizures in humans and epileptiform activity in laboratory animals. Recent evidence indicates that serotonin mediates both atropine-resistant cortical desynchronization and the suppression of focal epileptiform activity induced by noxious stimulation. As a large forebrain projection of serotonergic fibres originates from the dorsal raphe nucleus, involvement of this nucleus in altering cortical activity was investigated. Agents known to inhibit serotonergic unit activity including serotonin, (+/-)-8-hydroxy-dipropylaminotetralin, fluoxetine and baclofen, when pressure ejected in the vicinity of the dorsal raphe, prevented cortical desynchronization as well as the suppression of focal epileptiform activity in response to noxious stimulation. From these observations it is concluded that serotonergic neurones of the dorsal raphe can profoundly influence neocortical excitability and this action may underlie the clinical effectiveness of strong or noxious stimuli in suppressing epileptic seizures.
伤害性刺激会诱发皮质去同步化，进而可抑制人类的癫痫发作以及实验动物的癫痫样活动。最近的证据表明，血清素介导了抗阿托品的皮质去同步化以及伤害性刺激诱导的局灶性癫痫样活动的抑制。由于血清素能纤维的一大脑前投射起源于中缝背核，因此研究了该核在改变皮质活动中的作用。已知抑制血清素能单位活动的药物，包括血清素、（±）-8-羟基二丙基氨基四氢萘、氟西汀和巴氯芬，当在中缝背核附近通过压力注射时，可阻止皮质去同步化以及对伤害性刺激的局灶性癫痫样活动的抑制。从这些观察结果可以得出结论，中缝背核的血清素能神经元可深刻影响新皮质兴奋性，这种作用可能是强刺激或伤害性刺激在抑制癫痫发作方面临床有效性的基础。
