Reed S I
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Trends Genet. 1991 Mar;7(3):95-9. doi: 10.1016/0168-9525(91)90279-Y.
In budding yeast, Saccharomyces cerevisiae, the two principal cell cycle transitions, from G1 to S phase and from G2 to M phase, are controlled by the same protein from G2 to M phase, are controlled by the same protein kinase, CDC28, a homolog of the cdc2 protein kinase in fission yeast and other organisms. The G1 to S phase activity of the kinase is associated with accumulation of a novel family of G1 cyclins, distinct from cyclins that are required to activate the kinase for G2 to M phase functions. It remains to be determined whether G1 cyclins with similar functions exist in higher cells.
在出芽酵母酿酒酵母中，两个主要的细胞周期转换，即从G1期到S期以及从G2期到M期，从G2期到M期均由同一种蛋白激酶CDC28控制，CDC28是裂殖酵母和其他生物体中cdc2蛋白激酶的同源物。该激酶从G1期到S期的活性与一类新的G1细胞周期蛋白的积累相关，这类G1细胞周期蛋白不同于激活该激酶以实现从G2期到M期功能所需的细胞周期蛋白。高等细胞中是否存在具有类似功能的G1细胞周期蛋白仍有待确定。
