Cattapan-Ludewig Katja, Ludewig Stephan, Messerli Nadine, Vollenweider Franz X, Seitz Antonia, Feldon Joram, Paulus Martin P
University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
J Nerv Ment Dis. 2008 Feb;196(2):157-60. doi: 10.1097/NMD.0b013e318162aa1b.
Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.
对慢性精神分裂症患者的研究表明，患者在决策情境中会在刻板和不可预测的反应之间波动，这一现象被称为调节异常。本研究的目的是调查精神分裂症患者在疾病初期是否已经表现出调节异常行为。32名首发精神分裂症或精神分裂症样患者以及30名健康对照者完成了二选一预测任务。结果显示，首发患者的决策行为具有高度调节异常的特征，同时伴有低度量熵和互信息增加的趋势。这些结果表明，在二选一预测任务中的行为异常在疾病早期就已经存在。
