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通过检测一名12岁男孩外周血中的TSST-1 Vβ特征实现葡萄球菌中毒性休克综合征的早期诊断。

Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vbeta signature in peripheral blood of a 12-year-old boy.

作者信息

Ferry Tristan, Thomas Damien, Bouchut Jean-Christophe, Lina Gerard, Vasselon-Raina Maryline, Dauwalder Olivier, Gillet Yves, Vandenesch François, Floret Daniel, Etienne Jerome

机构信息

INSERM U851, Lyon F-69008, France.

出版信息

Pediatr Infect Dis J. 2008 Mar;27(3):274-7. doi: 10.1097/INF.0b013e31815c93a3.

DOI:10.1097/INF.0b013e31815c93a3
PMID:18277923
Abstract

We report the case of a 12-year-old boy who developed staphylococcal toxic shock syndrome associated with S. aureus pharyngeal colonization or infection. The diagnosis was rapidly confirmed by detecting the Vbeta signature of the toxic shock syndrome toxin-1 in peripheral blood, based on transient T cell depletion rapidly followed by massive expansion of Vbeta 2-positive T cells.

摘要

我们报告了一例12岁男孩的病例，该男孩患葡萄球菌中毒性休克综合征，与金黄色葡萄球菌咽部定植或感染有关。通过检测外周血中毒性休克综合征毒素-1的Vβ特征，基于短暂的T细胞耗竭后迅速出现Vβ2阳性T细胞的大量扩增，该诊断迅速得到证实。

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Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vbeta signature in peripheral blood of a 12-year-old boy.通过检测一名12岁男孩外周血中的TSST-1 Vβ特征实现葡萄球菌中毒性休克综合征的早期诊断。
Pediatr Infect Dis J. 2008 Mar;27(3):274-7. doi: 10.1097/INF.0b013e31815c93a3.
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Toxic shock syndrome: characterization of human immune responses to TSST-1 and evidence for sensitivity thresholds.中毒性休克综合征：人类对 TSST-1 免疫反应的特征及敏感性阈值的证据。
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